[rcsorensen]

Yes.

In the final analysis this question is equivalent to "Is it difficult to make a site that can have any piece of it fail to load or be removed at any time?" since website developers have no control over what may or may not make it onto the list of an adblocker.

[gkop]

JavaScript has had try/catch since forever though?

[tempestn]

Ad blockers don't just block third party things though. Or even necessarily sane things. Our site is a classified ad aggregator. At the time at least, we learned that Adblock Plus would just blithely delete any element with 'ad' as part of its class. (A major section of our results page had the class 'ad block' (ironically) and was blocked.)

Yes, these things can be worked around, but not every site maintainer will bother. (Especially since those adblock users likely don't earn them any direct revenue.)