The thing with these substances is that although these substances are best known for their psychological effects, they may also have some medically useful effects for somatic disorders. For example, some of the psychedelic phenethylamines and tryptamines are extremely effective agonists of 5-HT2A, which is a seretonin receptor found in the brain which modulates certain aspects of cognition. However, this receptor is also expressed throughout the body, and it seems to have something to do with rheumatoid arthritis. (This is why SSRIs are occasionally prescribed off-label for RA.) The phenethylamine DOI is actually such a strong agonist for this receptor that it is used in biology labs to study the receptor in vitro, and it has actually been studied and found to at least partially alleviate rheumatoid pain. [1][1] http://journals.plos.org/plosone/article/file?id=10.1371/jou...
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