Aluminum Should Now Be Considered a Primary Factor in Alzheimer’s Disease

[nilved]

Is The Aluminum Hypothesis Dead? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131942/

[gwern]

That seems to refute most of OP's points and bring up a lot of contradictory evidence that OP doesn't include at all.

[jxramos]

Cool, just the sort of history I was curious about regarding the origins of this hypothesis.

[iandanforth]

Red-flags:

- A journal name I don't recognize

- A single author from an institution that I don't recognize

- Use of absolute terminology 'unquestionably'

- Implied vague relationships between large biological systems 'sweating' reduces chances of Alzheimer.

[Florin_Andrei]

Also, I think it's an old idea, probably recycled. The title seemed very familiar, but from long, long ago, pre-2000 at least, maybe circa 1990.

Well, either that, or I got too much aluminum in my brain and I'm confused. :)

[stoshe]

Yeah, they totally seem legit...

http://i.imgur.com/FlCnduG.png

[alakin]

There is a genotype called ApoeE-e4/e4 which increases risk by 11x. https://snpedia.com/index.php/APOE

Interestingly the only differences between Apoe4 and a neutral, very common variant called ApoE3 is one amino acid at position 112. The small variance appears to account for most of the negative effect of the ApoE4 genotype. https://www.ncbi.nlm.nih.gov/pubmed/28533891

[pmontra]

TLDR: "Aging is the major risk factor for Alzheimer’s disease though the advent of Alzheimer’s disease within a normal human lifespan is suggested to be brought about through human exposure to aluminum. Essentially without aluminum in brain tissue there would be no Alzheimer’s disease."

[kbenson]

Wait, didn't aluminun used to be much more rare in the past, yet we still had Alzheimer's cases? Or are we assuming things in the past were Alzheimer's without good evidence?

Edit: Removed question about exposure, since it was answered in parent.

[CiPHPerCoder]

There's also a bad joke here.

Can't have Alzheimer's without Al.

EDIT: Oh come on HN, periodic table jokes are in right now.

[strangattractor]

More Redflags - A paper that doesn't have any experimental data - A single author paper (nobody to collaborate with) - A paper that uses many of the the author's previous papers as references

[michaelmu]

Have there ever been studies linking the aluminum in antiperspirant to development of Alzheimers?

[gjem97]

See comments elsewhere, the amount of aluminum absorbed from antiperspirant is dwarfed by dietary aluminum intake.

[Xeoncross]

...or even aluminum foil wrapping those delicious foods like stuffed potatoes?

[NikolaeVarius]

Note that this is an Editorial

[HarryHirsch]

An editorial in a journal that no one ever heard of by an author from an also-ran university. In medical research you can really only trust meta-studies, because attempts to find a simple cause for any complex disease are legion, and usually wrong.

[opportune]

Have any of you guys ever written or read scientific papers before? This is a pretty poorly written article and I'm surprised it has so many upvotes. It's a bold headline, but the article itself makes many logical leaps that are pretty sensational and unfounded.

Overall I'd say this is a pretty garbage article and that we shouldn't be upvoting it so much / only reading the headline and accepting it as fact.

[ef4]

This is a no-name journal with no reputation (positive or negative) that I can find. The aluminum hypothesis is widely rejected by mainstream researchers for pretty good reasons. User nilved posted a link to a comprehensive paper explaining why (go upvote them).

Please remember to be be skeptical of links like this. Being in "a journal" is not a high bar.

[rrggrr]

CPAP humidifiers... the heating plate is aluminum, right? Think of all the CPAP users absorbing Al through respiration.

[CountSessine]

Other than antiperspirant, are we exposed to aluminum in a form that our bodies readily absorb? Is it ever used as a food additive?

[reubenmorais]

Aluminium from antiperspirants is not readily absorbed. We ingest a lot more aluminium simply from our daily diets.

http://www.sciencedirect.com/science/article/pii/S0278691500...

[ianai]

I'm concerned about aluminum cookware. Though maybe it doesn't leach out?

Google edit- it definitely can leach.

[mywittyname]

Baked goods is the primary vector (it's very common in baking powder as mentioned). But it also has uses as acidity regulators in cheeses and pickles.

[danielhooper]

I believe there's some in coffee mate (a non-dairy creamer)

[sevensor]

Some baking powders (used in quick breads) contain aluminum.

[spoiledtechie]

Is it just deodorant or can drinking out if an aluminum soda can or even tin foil around food also cause such?

[hammock]

Aluminum cans are lined with BPA (polymer) .. not likely that this is a major vector. See Table 1.3 here[1] for a discussion of some sources, although it does not cover cans, pots and pans, or foil.

[1]https://www.atsdr.cdc.gov/phs/phs.asp?id=1076&tid=34

[mccada]

It is interesting how the editorial talks about perspiration being a natural way for the body to excrete aluminum, while aluminum is the active ingredient in most anti-perspirants. So we are effectively blocking the release of aluminum by using aluminum.

[aeriklawson]

I think the interesting part is that if you are not exercising regularly, you're not perspiring and hence blocking a major channel to excrete aluminum.

Diet and exercise, folks. I wouldn't worry about the aluminum in your deodorant - make sure you're living a healthy lifestyle overall.

[euroclydon]

Only in the arm-pits. There are plenty of other places to sweat when you're hot.

[moo360]

Okay, but what about Aluminium?

[njx]

How does cooking in aluminium vessels affect the body?

[derrickgrant]

Can someone tell the deodorant manufacturers please? It's very hard to find aluminium free anti-perspirant in the uk

[klodolph]

We should be clear and distinguish deodorants in general from antiperspirants specifically. Aluminum compounds are the only known effective antiperspirants, you can ask for an aluminum-free antiperspirant but you'll get a product that doesn't work very well (if at all). However, there are many options for aluminum-free deodorants that aren't antiperspirants.

I thought it was well known that antiperspirants should be avoided because of the aluminum.

[halite]

→ http://www.saje.com/ca/peaceful-warrior-4011.html → https://everymanjack.com/body/deodorant.html

I have used these and are not bad. See if you can get these in the UK.

[hammock]

Some big names that I've used. Speed Stick, Tom's.. usually it says "deodorant" on the label but not "anti-perspirant"

[2_listerine_pls]

What are common sources of Aluminium?

[mygo]

deodorant

[notadoc]

Where is the presumed aluminum exposure coming from?

I recently read about a relationship between alzheimers and pesticides.

https://www.nature.com/articles/srep32222

There is obviously much more to learn.

[franciscop]

Really interested here for my far future health as I'm starting a project with some CNC'd aluminum.

[blue1]

what about aluminum-based antacids?

[prodikl]

dude... does this mean antiperspirant is going to increase my risk of alzheimer's in the future?? what about aluminum cans and alumnium foil?

[pc86]

dude... there are a half dozen nearly identical comments on this thread that give you the answer to your question.