[abefetterman]

Reading their actual paper further, it seems I read a bit too much into the original article. However, as their paper mentions:

> The parameter space of C-2U has over one thousand dimensions. Quantities of interest are almost certainly not convex functions of this space. Furthermore, machine performance is strongly affected by uncontrolled time-dependent factors such as vacuum impurities and electrode wear.

I'm not aware of DOE procedures that are robust to these types of issues, and would certainly appreciate any literature you have on the subject.

Regardless of theoretical literature, this procedure has enabled a dramatic shift in how these scientists think about their experiment. Furthermore it has enabled them to achieve results much faster than before (if you have been following Tri Alpha, it has been a real slog). Both of these are exciting to me even if they don't break new ground in the design of experiments.