[schlagetown]

This article seems to gloss over possible physical causes for CFS/ME, sort of implying that nobody has any idea what physical basis there might be for it. But that's…not entirely true?

For example, there's at least some evidence linking it to mitochondrial dysfunction, see e.g.: https://me-pedia.org/wiki/Mitochondria

> There is evidence of mitochondrial dysfunction in chronic fatigue syndrome patients. Muscle biopsies have shown evidence of mitochondrial degeneration, deletions of mitochondrial DNA, the reduction of mitochondrial activity, and Sarah Myhill found measurable mitochondrial dysfunction correlating with severity of illness. Myhill also produced improvement by targeting those dysfunctions. Mitochondrial DNA variants correlate with symptoms, symptom clusters & symptom severity.

Far from conclusive, but I think worth at least noting.

From both reading a variety of sources on the topic, and having someone close to me with CFS/ME for many years, I think it's pretty clear that a) there's most likely a physical basis for it, b) we don't yet know how it works, and c) research on this is drastically underfunded.

Considering millions of people are affected, there should be way more resources put towards it. Hundreds of millions of dollars per year, to put it on par with funding of similar diseases. (See: https://www.meaction.net/2017/01/07/dimmock-mirin-jason-esti...)