This is a completely meaningless comparison. Even things that behave waaay more similar than cocaine and coffee in terms of brain chemistry can have even more disparate effects. And I was talking about the effects.
This meaningless comparison is a fundamental concept in psychopharmacology. Different substances can have different effects whilst acting on the same pathway. And to your point re: "effects"it should be noted the SAME substance can have very different effects (biphasic effects) depending on dose (alcohol being the key exmaple).
1_over_n|6 years ago
https://en.wikipedia.org/wiki/Mesolimbic_pathway
https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0...
https://www.ncbi.nlm.nih.gov/pubmed/9884132