This was a very exciting title but a very dodgy article. It references two independent areas of active research but concludes one doesn't work in practice yet and the other (which is buried in this report [0] from Columbia from 2013) works only in rats with stem cells and growth factors. So surely, either the title is misleading about this being viable for humans yet, or there is more progress on the subject beyond what is here and there is a better and more recent source available. Either way, an exciting topic I've also been wondering about for a long time.
When I had testicular cancer, they found an entire molar in that tumor.
Apparently I had a type of cancer that just spontaneously grows parts of you inside it. I am ashamed to say that I forgot the name of this type of cancer.
> Tooth repair mechanisms that promotes dentine reinforcement of a sponge structure until the sponge biodegrades, leaving a solid dentine structure. In 2016, the results of animal studies were reported in which 0.14 mm holes in mouse teeth were permanently filled.
GSK3 inhibitors are interesting, but we don't understand much the subtypes that are likely to exist: "GSK-3 appears to both promote and inhibit apoptosis, and this regulation varies depending on the specific molecular and cellular context."
Still, I believe better GSK3i will find a role in autologous bone-marrow grafting therapies to fight senescence: with TERC/TERT overexpression (the opposite of DeGrey WILT ideas) to send new stem cells to the tissues - just like how you can find the donors chromosomes in most tissues of grafted patient.
Once I was watching the news, probably back in the 70s - the reporter was Peter Jennings, and he saying that the Soviets had created an aquatic chicken with gills instead of lungs. Never any follow up, never any mention of it again. I’ve always wondered if the people at ABC News were just incredibly gullible, or if the government swooped in to suppress the story.
Every couple years an article like this comes out, yet nothing of substance actually happens.
Maybe if they combine this latest greatest teeth growing technology with the latest greatest new battery technology, they'd be able to get it to market.
"The REPLICATE System can only be used if the root of the original tooth is still in place. Also your dentist will need to evaluate if the surrounding bone structure is healthy enough to accept a REPLICATE Tooth."
Do you have a link? I’m pretty interested in this field, and as far as I know all the 3D printing tooth companies are just using the same old materials. Most labs can already CNC you a tooth the same day. All of the “bio-printing” stuff I’ve seen thus far is marketing BS.
Was just joking with my dentist about this. As a kid and teenager I was very bad about brushing and only flossed if I had something painful stuck in my teeth, I’ve paid for it with tons of cavities. She said I need to be careful about how hard I floss now because I could damage the fillings and then will need implants for some of them. I jokingly replied that hopefully by the time the need arose science would be able to regrow a full set of teeth for me.
My dentist hates google, internet, science reporting, etc. Patients are always asking about miracle cures.
So for years now I poke the bear by excitedly asking about some new treatment I had "just read about" (meaning I just made it up). Stem cells, nanobots, lasers, supplements, etc.
It's fun to see him get spun up. He's so serious, earnest. Slow to catch on that I'm poking him.
I’ve been seeing articles about this since the 90s. I don’t think it will ever happen. Even if we had the technology, dealing with stem cells would be super expensive compared to doing a bridge or implant.
And for whatever reason, dentistry is an extremely conservative field.
I’ve been dreaming about this for forty years - ever since I read about some guy that got irradiated by a UFO and a couple months later his teeth started falling out and they found a brand new set growing in beneath them. Wouldn’t it be nice?
I think they have made some advances towards this in the UK also though it’s targeted at accident victims needing major facial reconstruction.
It would also be interesting to see how long elephants might live if we could regrow their teeth - disease and predators aside that seems to be the limiting factor to their life span at the moment.
There are multiple gum grafting techniques that can be used if the area is not too far gone. This is already an issue with dental implants and those are a proven effective option.
Why grow new biological teeth? We have the material to create and implant fake teeth that are better in every way. The real question should be when will it become more practical to simply replace a tooth rather than fill/cap/drill to save the biological tooth.
This is simply not true. Composites of today are still more brittle and fragile than human teeth. Also when implants are placed you're removing bone in order to place them. This can, and often does, weaken the placement region. Finally you're at higher risk of sinus perforation during extractions among other, generally permanent, complications. My SO is a DSS who does all of this and if you can keep your real teeth, they're almost always superior. Dr. Seuss had it right.
Problem with implants is that they cause compressive stress to the bone, which causes bone to deteriorate.
Teeth are held by
https://en.wikipedia.org/wiki/Sharpey%27s_fibres. This converts the forces acting on the tooth to
tensile stress on the bone, which causes it to grow more dense.
[+] [-] dsukhin|6 years ago|reply
[0] https://techventures.columbia.edu/news-and-events/latest-new...
[+] [-] naikrovek|6 years ago|reply
When I had testicular cancer, they found an entire molar in that tumor.
Apparently I had a type of cancer that just spontaneously grows parts of you inside it. I am ashamed to say that I forgot the name of this type of cancer.
[+] [-] RyJones|6 years ago|reply
[0]: https://en.wikipedia.org/wiki/Teratoma
[+] [-] taf2|6 years ago|reply
The idea that our cells forget what they are supposed to be.
[+] [-] layoutIfNeeded|6 years ago|reply
[+] [-] unknown|6 years ago|reply
[deleted]
[+] [-] AdmiralAsshat|6 years ago|reply
[+] [-] unknown|6 years ago|reply
[deleted]
[+] [-] MattPalmer1086|6 years ago|reply
[+] [-] tekproxy|6 years ago|reply
[+] [-] westurner|6 years ago|reply
Tideglusib https://en.wikipedia.org/wiki/Tideglusib
[+] [-] minxomat|6 years ago|reply
Very interesting mechanism.
[+] [-] 1996|6 years ago|reply
Still, I believe better GSK3i will find a role in autologous bone-marrow grafting therapies to fight senescence: with TERC/TERT overexpression (the opposite of DeGrey WILT ideas) to send new stem cells to the tissues - just like how you can find the donors chromosomes in most tissues of grafted patient.
[+] [-] PedroBatista|6 years ago|reply
Maybe when the hens grow teeth, as the french say we'll be able to do that in humans too.
[+] [-] zxcvbn4038|6 years ago|reply
[+] [-] Covzire|6 years ago|reply
[+] [-] technothrasher|6 years ago|reply
Maybe if they combine this latest greatest teeth growing technology with the latest greatest new battery technology, they'd be able to get it to market.
[+] [-] propercoil|6 years ago|reply
[+] [-] Causality1|6 years ago|reply
[+] [-] arkades|6 years ago|reply
It’s already got its patents granted and is transitioning from prototypes to production units, IIRC.
[+] [-] kbutler|6 years ago|reply
So the bioprinting is an alternative means to construct a replicate tooth (as opposed to CNC milling).
Replicate teeth can be used as a less invasive/quicker healing alternative to implants under some conditions:
https://www.replicatetooth.com/for-patients/
"The REPLICATE System can only be used if the root of the original tooth is still in place. Also your dentist will need to evaluate if the surrounding bone structure is healthy enough to accept a REPLICATE Tooth."
[+] [-] wmeredith|6 years ago|reply
[+] [-] malandrew|6 years ago|reply
[+] [-] vxNsr|6 years ago|reply
[+] [-] kachurovskiy|6 years ago|reply
[+] [-] specialist|6 years ago|reply
So for years now I poke the bear by excitedly asking about some new treatment I had "just read about" (meaning I just made it up). Stem cells, nanobots, lasers, supplements, etc.
It's fun to see him get spun up. He's so serious, earnest. Slow to catch on that I'm poking him.
Before he pokes me.
[+] [-] mrfusion|6 years ago|reply
And for whatever reason, dentistry is an extremely conservative field.
[+] [-] carapace|6 years ago|reply
[+] [-] zxcvbn4038|6 years ago|reply
I think they have made some advances towards this in the UK also though it’s targeted at accident victims needing major facial reconstruction.
It would also be interesting to see how long elephants might live if we could regrow their teeth - disease and predators aside that seems to be the limiting factor to their life span at the moment.
[+] [-] rasputinlives|6 years ago|reply
[+] [-] JoeAltmaier|6 years ago|reply
[+] [-] nsxwolf|6 years ago|reply
[+] [-] kbutler|6 years ago|reply
[+] [-] helge9210|6 years ago|reply
[+] [-] rasz|6 years ago|reply
[deleted]
[+] [-] sandworm101|6 years ago|reply
[+] [-] windexh8er|6 years ago|reply
[+] [-] KillerDiller|6 years ago|reply
[+] [-] whiddershins|6 years ago|reply
[+] [-] gwbas1c|6 years ago|reply
I have a lot! They are more durable than biological teeth, the main drawback is that I need to be a bit more careful flossing.
Honestly, I'm not sure what's better, in the long run: An implant or regrowing a tooth. I guess it will really just come down to what's cheaper.