Does this mean that those already on these drugs are more resistant to the new variant of coronavirus, or more susceptible because their normal regime of medication isn’t able to remediate?
SARS shares an enzyme that is similar enough to the HIV protease that people tried the HIV protease inhibitors on SARS and they seemed to work. This coronavirus has a very similar enzyme so it’s the same idea
It might be - ironically - due to that Indian group's preprint with crappy method that suggested the virus was intentionally hybridised from HIV and coronavirus.
anonuser123456|6 years ago
Sample size of 1, but in both cases, the patient appears to have gone from very sick to normal vitals in 48 hrs.
The really nice thing about lopinavir/ritonavir if it works will be... we've already got a lot of it.
Edit: Both cases being the separate administrations of remdesivir & lopinavir/ritonavir.
carrozo|6 years ago
pasttense01|6 years ago
Jyaif|6 years ago
danarlow|6 years ago
quickquackquock|6 years ago
https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1....
If you took that preprint at face value, before the flaws were pointed out e.g.
https://www.reddit.com/r/science/comments/ewtmnq/uncanny_sim...
https://www.reddit.com/r/science/comments/ewtt6f/uncanny_sim...
https://www.reddit.com/r/science/comments/ewtt6f/uncanny_sim...
Then mixing up a cocktail of flu and HIV anti-virals would be a smart move.
If this result pans out, it might just be a remarkable piece of serendipity from some shitty science.