For anyone thinking to simply host assets in S3 (i.e. skip the Cloudfront part), please do not. I'm not sure if it's my ISP throttling it, or the routing, but from where I am in Europe, accessing a file from an S3 bucket in us-east often results in speeds less than 100kbit/s. The same files served from Cloudfront will saturate my connection (gigabit).
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