[try-perforate]

This vaccine is against the entire spike glycoprotein. Some in production vaccines are only against the RBD (the protein that actually latches onto ACE2). There are variants out there that have been shown to escape RBD antibodies. However, since this vaccine encodes the entire spike, there are other areas that antibodies can bind to. They stated in their press release that the vaccine elicits a Th1, CD4+, and CD8+ T-cell response against both the RBD and other areas on the spike. I think this is the most promising aspect. This means it should hopefully be effective against even escape variants.

[m4eta]

Can you tell me why I shouldn't worry that vaccines which are made to flood the body with fake ACE2 proteins won't affect blood pressure, body water and sodium content? What happens to all the angiotensin II that connects to dummy ACE2 connectors?

[zebrafish]

I haven’t seen what you’re describing. I’ve seen hrsACE2 which is recombinant ACE2. That will both provide a target for the virus to latch onto as well as supplement the body’s actual ACE2 to complete the cycle which seemed to be more of the focus.

[hcknwscommenter]

>vaccines which are made to flood the body with fake ACE2 proteins

There is no such thing as a vaccine that floods the body with fake ACE2 proteins.

[gilbetron]

That's a therapy being worked on, not a vaccine.