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jeffxtreme | 5 years ago

Agree this is great to hear, but the fact that they had X-ray diffraction data indicates this protein was indeed crystallizable no?

Though the next paragraph in the article shows that DeepMind is indeed working on mapping out reliability:

"Demis Hassabis, DeepMind’s co-founder and chief executive, says that the company plans to make AlphaFold useful so other scientists can employ it. (It previously published enough details about the first version of AlphaFold for other scientists to replicate the approach.) It can take AlphaFold days to come up with a predicted structure, which includes estimates on the reliability of different regions of the protein. “We’re just starting to understand what biologists would want,” adds Hassabis, who sees drug discovery and protein design as potential applications."

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flobosg|5 years ago

> Agree this is great to hear, but the fact that they had X-ray diffraction data indicates this protein was indeed crystallizable no?

Yes. CASP uses as targets proteins with no known published structure but a solved or soon-to-be-solved one. They are then kept on hold until the end of the competition.