[agytvfr]

> How much Tylenol would a person have to consume over a two month period to permanently damage their liver

Liver damage can occur after a single incident. People have died from single time overdoses of paracetamol. There is a quick fix in an ER of giving NAC which can help eliminate most of the damage, but there is a small window(a day or two) where it is effective.

[kridsdale1]

I have a load of NAC on hand. Would it be a good idea to take it whenever I take Tylenol? I can't imagine a pharma pathway that would result in it attenuating the painkiller effect. Just mop up the oxidative damage.

[agytvfr]

Not a doctor and I wouldn't listen to medical advice from HN, but you can find a lot on this:

>Therefore, it may be beneficial to administer APAP(Tylenol) in combination with NAC routinely to reduce rates of liver failure and death. Because NAC's main role is to reduce the accumulation of APAP's toxic metabolites, the concomitant administration of NAC should have no impact on the efficacy of APAP as an antipyretic and analgesic.

From: https://clinicaltrials.gov/ct2/show/NCT01137591 .

[IfOnlyYouKnew]

Read the label. Switch to Aspirin, either completely or half/half. If possible, try fixing the underlying problem, not the pain.