Thus, the system not only allows for recirculation of bodily fluid, but it also provides a means for the immune system to sift through material from around the body in order to scan for infection. Without lymphatics, fluid would build up in body tissues, and there would be no way to alert the adaptive immune system to invading pathogens.
Something medical texts tend to not spell out:
Lymph is more or less blood, minus certain blood parts (like red blood cells). And when it gets into the tissues it gets called interstitial fluid.
This is all the same fluid circulating through the body, with different elements added or removed in different contexts. It's really quite elegant and you can think of it sort of like the water cycle. (https://water.usgs.gov/edu/watercycle-kids-adv.html)
Interstitial fluid would be sort of like groundwater. And like groundwater, it gets into the tissues via seepage.
The circulatory system would be kind of like rivers and streams.
So part of this fluid cycle is controlled by the pump action of the heart. When it is in your blood vessels (and I think also when it is in the lymphatic system), the heart pumps it, driving the circulation.
When it is out in the tissues, it is beyond the reach of the heart. And this is where things get really fascinating.
It is driven back to the circulatory system via two different methods, depending on where it is. The brain has a separate system from the rest of the body.
In the brain, the glymphatic system flushes fluids from the tissues while you sleep. This is a primary function of sleep and flushing these fluids out is how the body "takes out the trash," which is likely why sleep deprivation is increasingly shown as associated with both the build-up of certain proteins in the brain and, ultimately, certain brain disorders.
In other tissues, muscle action drives the fluid back to the circulatory system. (Remember, the heart is just a big muscle. So this makes perfect sense.) So exercise dramatically increases the rate at which interstitial fluid gets returned to the circulatory system.
This means that one of the functions of exercise is "taking out the trash." And this is likely a huge and overlooked factor in why exercise is so beneficial to your health.
Different sources cite different rates, but exercise may increase the outflow by as much as eight times the normal speed of outflow via seepage. It's really a big difference.
If you have any health issues, understanding this human internal "water cycle" is something I highly recommend as enormously helpful. I sometimes take a walk to help myself feel better and I know that at least part of why that sometimes helps is it clears waste products from my tissues by pumping up the volume -- literally -- on the body taking out the trash.
> In the brain, the glymphatic system flushes fluids from the tissues while you sleep. This is a primary function of sleep and flushing these fluids out is how the body "takes out the trash," which is likely why sleep deprivation is increasingly shown as associated with both the build-up of certain proteins in the brain and, ultimately, certain brain disorders.
As someone who's severely sleep-deprived, can you please share more / share a source? Thanks in advance
> sift through material from around the body in order to scan for infection. Without lymphatics, fluid would build up in body tissues, and there would be no way to alert the adaptive immune system to invading pathogens
sift/scan/alert/invade
I always find it interesting how much agency we assign these systems when we describe them. Listen to some of the descriptions of our genetic machinery, you’ll hear the same thing. I understand much of it is to help the audience understand, but even when you dive deep into a topic it doesn’t seem to go away entirely.
It is truly astounding how little we know about ourselves and how every new discovery unlocks so much potential. If our rate of scientific progress continues to rise I am incredibly excited for the next 100, and 1000 years- even if I won’t be around to see it.
The one that still gets me is the little understood role of gut bacterial, seems like that subsystem is incredibly incredibly important yet we understand so little about it.
Any other example of recently discovered body parts?
I remember the recent discovery of a new tissue in the eye that is one cell wide which explain why it has been discovered only recently. I expect a few other remaining extremely small (in surface or in width) new tissues to remain undiscovered.
Which ask the question: would it be possible to cut an organ incrementally (ideally one cell width at a time (e.g with a powerful laser like for transistors)) it would enable an exhaustive search!
There have been people who were (presumably with consent) frozen in gelatin after death, and then "sliced" (by shaving off layers) very thinly and imaged to create volumetric models. I don't know if they had enough resolution to see individual cells.
I think there has been a bit of debate among retina specialists as to whether this constitutes a new tissue or a guy looking to name an already well known existing phenomenon after himself
“ meaning we’ve been wrong about some basic ways in which the brain and immune system are connected.” I’ve been screaming this at my doctors for years. For those who don’t want to read the article, the quote sums it up. They discovered new lymphatic vessels in the brain in 2016 where previously the brain wasn’t thought to have any.
2 years ago I had a stressful life event. I became schizophrenic because of it. I accidentally discovered that ketosis cures the schizophrenia. It turns out a doctor at Harvard has been sounding the alarm about this and nobody is listening to him [1].
After researching these things somewhat deeply, it appears that almost all diseases that involve the death or inactivity of neurons (Alzheimer’s, schizophrenia, autism, etc) are sometimes caused by “inflammatory signals,” as I call them, which interfere with the metabolism of glucose. Note the way I worded that — there’s more than one way for those neurons to become deactivated. What we currently think of as being a single disease might be many diseases, many different types of pathology that ultimately lead to the silencing of the same general population of neurons and thereby causing the same symptoms. The point is that the metabolic angle doesn’t explain all neural pathology, so keep that in mind when ketosis is found to only put 20% of schizophrenics into remission in the next five years.
There is currently exactly one study looking at the effect of ketosis on schizophrenia, in Finland, and it keeps getting delayed.
When a cells glucose metabolism is interfered with by inflammatory signals, ketone metabolism is not affected apparently. Plaques are a downstream effect of metabolic dysfunction, not the cause.
Doctor Mary Newport has been sounding the alarm for years after witnessing the remission of her husbands Alzheimer’s following administration of ketogenic foods and nobody is listening to her [2].
Doctor Robert Naviaux at UC San Diego is provoking astounding recoveries in children with autism with a drug that is thought to interfere with immunological signaling [3]. If you have chronic fatigue syndrome, pay close attention to this.
In a bizarre plot twist, people who eat nothing but beef are experiencing the most miraculous recoveries from autoimmune problems that I have seen so far in becoming preoccupied with this general area of research [4][5]. It appears that ketone bodies are somewhat anti-inflammatory [6] but their main benefit is providing fuel that can power cells that are being shut down by inflammatory signals, whereas the carnivore diet seems to deactivate inflammation that is currently underway for many people.
This is 100% a medical revolution that is still in the pipes. The work being done in this area of brain inflammation and inflammation in general will rock the medical establishment, cure thousands of diseases seemingly overnight and turn a burning light onto the cruel and sordid apathy that has infected western medicine in the last 80 years.
It's not just mental health that the ketone diet could contribute to, but other aspects of immunity as well. A recent paper showed that a normally-dormant subset of T-cells was activated during ketosis, and that this led to protection of mice from the influenza virus:
Ketogenic diet activates protective γδ T cell responses against influenza virus infection.
Total layman here and know almost nothing about biology. But I'm skeptical of this comment mainly because your sources are youtube videos. Which of course doesn't necessarily mean they're wrong, but I wanted to go over some of the people behind these. Some of them (e.g. Dr. Steve Phinney) seem like area experts, some I wasn't able to verify credentials of (e.g. Dr. Mary Newport) and some seem to have controversial (and possibly fringe?) opinions regarding nutritional science (i.e. Jordan Peterson, who is a psychologist not a medical expert).
So may I please ask experts chime in here, how reliable information in this comment? What are some papers one can read on this issue? [1]
[1] Except obviously OP. But OP is from 2016, and if this is understood, I expect there to be more papers on this? Also the relationship between parent comment and OP paper isn't clear to me, so maybe an expert can explain whether the parallel is justifiable.
But it turns out we discover fairly major new things about the body fairly frequently.
2018 - did scientist really no know what 20% of the fluids in the body are?: "The ground-breaking discovery of the new organ meant that old mysteries could be solved. For instance, scientists always knew that 20 per cent of body fluids were missing in a total tally, in between blood, lymph, serum and other bodily fluids" https://www.abc.net.au/news/2018-03-28/scientists-discover-n...
There's a lymph system in the brain that was so subtle that it went undiscovered until 2016. Lymph nodes are centralized pathogen collectors in the body's immune response system that allow the body to determine an appropriate immune response. There may be a connection between immune response and cognition, now that these nodes have been discovered in the brain. Not much else is known at this time.
There is a SCP that is used in the Ad astra canon. A book that shows how to remove any body part with certain pressure applied around it. They basically have a guy walk in to a donor center for a full donation and the surgeons pull him apart without any trauma and go to lunch. Has something to do with a extra brain lobe, augen lapen. Where the humans in that book are shown to have that and we do not.
[+] [-] DoreenMichele|5 years ago|reply
Something medical texts tend to not spell out:
Lymph is more or less blood, minus certain blood parts (like red blood cells). And when it gets into the tissues it gets called interstitial fluid.
This is all the same fluid circulating through the body, with different elements added or removed in different contexts. It's really quite elegant and you can think of it sort of like the water cycle. (https://water.usgs.gov/edu/watercycle-kids-adv.html)
Interstitial fluid would be sort of like groundwater. And like groundwater, it gets into the tissues via seepage.
The circulatory system would be kind of like rivers and streams.
So part of this fluid cycle is controlled by the pump action of the heart. When it is in your blood vessels (and I think also when it is in the lymphatic system), the heart pumps it, driving the circulation.
When it is out in the tissues, it is beyond the reach of the heart. And this is where things get really fascinating.
It is driven back to the circulatory system via two different methods, depending on where it is. The brain has a separate system from the rest of the body.
In the brain, the glymphatic system flushes fluids from the tissues while you sleep. This is a primary function of sleep and flushing these fluids out is how the body "takes out the trash," which is likely why sleep deprivation is increasingly shown as associated with both the build-up of certain proteins in the brain and, ultimately, certain brain disorders.
In other tissues, muscle action drives the fluid back to the circulatory system. (Remember, the heart is just a big muscle. So this makes perfect sense.) So exercise dramatically increases the rate at which interstitial fluid gets returned to the circulatory system.
This means that one of the functions of exercise is "taking out the trash." And this is likely a huge and overlooked factor in why exercise is so beneficial to your health.
Different sources cite different rates, but exercise may increase the outflow by as much as eight times the normal speed of outflow via seepage. It's really a big difference.
If you have any health issues, understanding this human internal "water cycle" is something I highly recommend as enormously helpful. I sometimes take a walk to help myself feel better and I know that at least part of why that sometimes helps is it clears waste products from my tissues by pumping up the volume -- literally -- on the body taking out the trash.
I think that's everything I wanted to say.
[+] [-] airstrike|5 years ago|reply
As someone who's severely sleep-deprived, can you please share more / share a source? Thanks in advance
[+] [-] Aerroon|5 years ago|reply
Could one of the effects of massage be something similar?
[+] [-] invalidOrTaken|5 years ago|reply
[+] [-] raducu|5 years ago|reply
[+] [-] jcims|5 years ago|reply
sift/scan/alert/invade
I always find it interesting how much agency we assign these systems when we describe them. Listen to some of the descriptions of our genetic machinery, you’ll hear the same thing. I understand much of it is to help the audience understand, but even when you dive deep into a topic it doesn’t seem to go away entirely.
[+] [-] bserge|5 years ago|reply
[+] [-] crispyporkbites|5 years ago|reply
[+] [-] neom|5 years ago|reply
[+] [-] The_rationalist|5 years ago|reply
[+] [-] wiml|5 years ago|reply
[+] [-] nitrogen|5 years ago|reply
[+] [-] neom|5 years ago|reply
[+] [-] selimthegrim|5 years ago|reply
[+] [-] unknown|5 years ago|reply
[deleted]
[+] [-] PIKAL|5 years ago|reply
2 years ago I had a stressful life event. I became schizophrenic because of it. I accidentally discovered that ketosis cures the schizophrenia. It turns out a doctor at Harvard has been sounding the alarm about this and nobody is listening to him [1].
After researching these things somewhat deeply, it appears that almost all diseases that involve the death or inactivity of neurons (Alzheimer’s, schizophrenia, autism, etc) are sometimes caused by “inflammatory signals,” as I call them, which interfere with the metabolism of glucose. Note the way I worded that — there’s more than one way for those neurons to become deactivated. What we currently think of as being a single disease might be many diseases, many different types of pathology that ultimately lead to the silencing of the same general population of neurons and thereby causing the same symptoms. The point is that the metabolic angle doesn’t explain all neural pathology, so keep that in mind when ketosis is found to only put 20% of schizophrenics into remission in the next five years.
There is currently exactly one study looking at the effect of ketosis on schizophrenia, in Finland, and it keeps getting delayed.
When a cells glucose metabolism is interfered with by inflammatory signals, ketone metabolism is not affected apparently. Plaques are a downstream effect of metabolic dysfunction, not the cause.
Doctor Mary Newport has been sounding the alarm for years after witnessing the remission of her husbands Alzheimer’s following administration of ketogenic foods and nobody is listening to her [2].
Doctor Robert Naviaux at UC San Diego is provoking astounding recoveries in children with autism with a drug that is thought to interfere with immunological signaling [3]. If you have chronic fatigue syndrome, pay close attention to this.
In a bizarre plot twist, people who eat nothing but beef are experiencing the most miraculous recoveries from autoimmune problems that I have seen so far in becoming preoccupied with this general area of research [4][5]. It appears that ketone bodies are somewhat anti-inflammatory [6] but their main benefit is providing fuel that can power cells that are being shut down by inflammatory signals, whereas the carnivore diet seems to deactivate inflammation that is currently underway for many people.
This is 100% a medical revolution that is still in the pipes. The work being done in this area of brain inflammation and inflammation in general will rock the medical establishment, cure thousands of diseases seemingly overnight and turn a burning light onto the cruel and sordid apathy that has infected western medicine in the last 80 years.
https://youtu.be/06e-PwhmSq8
[1] https://youtu.be/eQwRSuwRP9c
[2] https://youtu.be/Ux68qHr4CnI
[3] https://youtu.be/iWWF5nN7fUA
[4] https://youtu.be/N39o_DI5laI
[5] https://youtu.be/HLF29w6YqXs
[6] https://youtu.be/A5_R13Luit0
[+] [-] pazimzadeh|5 years ago|reply
Ketogenic diet activates protective γδ T cell responses against influenza virus infection.
https://immunology.sciencemag.org/content/4/41/eaav2026
[+] [-] gnulinux|5 years ago|reply
So may I please ask experts chime in here, how reliable information in this comment? What are some papers one can read on this issue? [1]
[1] Except obviously OP. But OP is from 2016, and if this is understood, I expect there to be more papers on this? Also the relationship between parent comment and OP paper isn't clear to me, so maybe an expert can explain whether the parallel is justifiable.
[+] [-] treeman79|5 years ago|reply
Brain fog is a common part of this.
Getting inflammation under control becomes your life.
Lots of successes (not all)
Autoimmune protocol Diet is meant for controlling inflammation.
It’s almost a Keto diet, but some Kinds carbs allowed, some things not allowed.
Overall your hives with personal experience and my own research.
[+] [-] nl|5 years ago|reply
But it turns out we discover fairly major new things about the body fairly frequently.
2018 - did scientist really no know what 20% of the fluids in the body are?: "The ground-breaking discovery of the new organ meant that old mysteries could be solved. For instance, scientists always knew that 20 per cent of body fluids were missing in a total tally, in between blood, lymph, serum and other bodily fluids" https://www.abc.net.au/news/2018-03-28/scientists-discover-n...
2020 - extra saliva glands inside our head no one knew about: https://www.sciencemag.org/news/2020/10/you-may-have-new-org...
[+] [-] mrwnmonm|5 years ago|reply
[+] [-] anonytrary|5 years ago|reply
[+] [-] rolph|5 years ago|reply
this is a newly recognized feature.
it makes sense considering some neurological disorders seem to be associate with immune dis/function
[+] [-] mensetmanusman|5 years ago|reply
[+] [-] nonce42|5 years ago|reply
On the other hand, the existence of the G-spot has been controversial for almost 40 years so reproducibility can't be taken for granted.
[+] [-] Blikkentrekker|5 years ago|reply
Methinkss that that'd be hard to not be reproducible.
[+] [-] coolreader18|5 years ago|reply
[0]: http://www.scpwiki.com/scp-2828
[+] [-] downrightmike|5 years ago|reply
[+] [-] neuralzen|5 years ago|reply
[+] [-] brundolf|5 years ago|reply
[+] [-] floatingatoll|5 years ago|reply
[+] [-] Cthulhu_|5 years ago|reply
[+] [-] peanut_worm|5 years ago|reply
[+] [-] scinerio|5 years ago|reply
[+] [-] dmak|5 years ago|reply
[+] [-] unknown|5 years ago|reply
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