Not quite, at least not necessarily. One feature of FTDI chips is an EEPROM that can be used to customize the enabled features, enumeration strings, and other things. That programming could probably be done in a separate jig, or in-circuit. So yes, 5 minutes of hardware work, but more potential rework at a higher level.
Not to mention the possibility of sealed cases/enclosures or potted PCBs.
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