[fifthofhisname]

It was clear from the start that SARS-CoV-2 would become endemic. Very interesting write up + data here.

> Cure-Hub's data shows less antibody diversity in vaccinated individuals than naturally infected individuals. Fewer unique antibodies provide the virus with an avenue for immune escape through S protein mutations.

The data compares natural immunity vs vaccinated immunity. I'm curious to see this data compared against individuals who were infected and were then vaccinated vs. individuals who were vaccinated then infected.

[criticaltinker]

I have no primary sources to offer regarding this question.

But here's some pure speculation if you're interested - assuming immunological memory operates in a 'most recently used' fashion, then it would follow that individuals will develop an immune response that trends toward being most effective at neutralizing the viral profile that was last seen. Consequently, the studies and data that evaluate natural immunity vs vaccinated immunity could be fairly applicable. In practice I'm sure you'd see a blending of the two immune responses, but timing of exposure could play a big factor in weighting that balance.