(no title)
amrcnimgrnt | 4 years ago
"mRNA vaccines have been tested in humans since 2011"
So barely 10 years. A study on a dozen or so participants, all white, college aged men with largely identical diets. I guarantee you that not one participant in the 2011 study was pregnant. (Btw, I looked at your reference. A Bush era press release was less manipulative. There wasn't a single peer-reviewed reference. All press releases and from interested parties)
Compare that with other vaccine technologies for which we have centuries of data, and inoculation in general for which we might have a thousand years worth of safety data.
Or did we forget about all the inconvenient facts about drug testing? We appear to have forgotten all the research done about regulatory capture and all the ineffective and unsafe pharmaceuticals the FDA approves.
But, nvm. #BelieveTheScience and de-platform anyone who asks inconvenient questions. And let's compartmentalize away the replication crisis modern science is going through.
Also, for some of us 10 years is not very impressive at all. "It's not new, nRNA has been around since the 90s!" is a massive value judgement for the word "new". Not all of us work developing webpages with 3 month old technology stacks!
Buttons840|4 years ago
amrcnimgrnt|4 years ago
I don't think a society can be as "advanced" as Star Trek. Societies are hard. To abuse CS terminology, they're NP-hard (or harder?). Star Trek seems to have only external threats, all internal problems are solved. The most boring problem a real society has is that of production and it is definitely NP-hard (see Hayek?). Star Trek has not only solved that at galactic scales, but has solved much hard problems than production.
Nor I don't think Star Trek is advanced in the sense that I would consider it "progress" vs. just change. I view Star Trek as the propaganda reel of (not for, of) a techo-distopia. Vulkans and that Data android fellow freak me out more than the Klingons whose society, while brutal, I can understand. I see more humanity in a Klingon because I can see a human society degenerating into the Klingons'. I don't see any humanity in Vulcans.
Btw, their technology bores me. Their tech is either impossible (warp drives). Surpassed (communicators). Or fraught with angels-dancing-on-pins philosophical questions (the "beam me up scotty" machines)
So, with the caveat that you used ST as an example and I'm definitely not a Trekkie, let me address your question:
No, I don't.
Biological systems are far more complicated than any system mankind has made. Every "cure" or therapy is really a very good whack-a-mole with hopefully lots of statistical information to back it up.
Take blood. It has hundreds, if not thousands, of components. Some are in pg/dL level of concentrations (that's 10^-12g / 100ml). See this chart [1]. How can we every really understand all the interactions among those various components?
That is not to say that I'm a bio-luddite (I am, but that's besides the point). Take penecillin. It's brutal on the body, but is one of the most important discoveries in human history. It has saved millions, if not billions, of lives. Im very grateful for penicillin, and yet, what an illustrative example! We gave too much penicillin with too much abandonment. So now, we have anti-biotic resistant bacteria. And, almost 90 years after it's first discovery we're finally starting to understand it's role in the havoc in our gut flora.
Btw, gut flora is another, fascinating, example of how complicated bio-systems are. We're evolved to depend on a symbiotic relationship with a gut flora that we've destroyed over the last 70 years of anti-biotics and cheap sugar.
So, while I think ab-initio methods (what Star Trek does) can inform and accelerate drug discovery (I worked on that briefly in my PhD), ultimately, no, I don't think we can ab-initio drugs through the whole pipeline (need-->development-->safety_evals-->approval).
[1] https://upload.wikimedia.org/wikipedia/commons/7/7c/Referenc...