[taylortbb]

> There are numerous bodies of data supporting waning immunity at this point.

Why that happens is less clear though. Is it a fault of mRNA tech itself? Or the dosing schedule? 21 days is very close together for a 2 dose vaccine, most are 6 months or years apart.

Using 21 days was a good way to get the trials done fast, if they'd used 6 months we'd be where we were 5 months ago, but this was one of the risks. Canada, which spaced doses out further, isn't seeing nearly as high of a rate of breakthrough cases.

I'm not saying we can conclude definitely that dosing is the problem, but it's a question worth investigating before coming to any firm conclusions that mRNA vaccines aren't good enough.

[catdog]

Agree it seems likely that dosing plays a fundamental role.

Moderna while still seeming to suffer from this problem seems to be suffering less than Biontech, they are very similar in general, biggest difference is Moderna having already a longer minimum waiting period between the shots and a way bigger dose of mRNA per shot. So this may already be a hint.

Also currently it looks like a third shot is giving a really great boost compared to the second one, at least in the short term. Same with using mRNA as a booster shot after a vector based vaccine.