I completely agree on your first point. I was going for a bit of understatement, but to be clear, doing any of that is firmly on the other side of many revolutionary breakthroughs in our understanding of biology. But that being said, the standard for success isn't to have an immune system that can protect a complete animal for its entire life. The standard is to put up a nonzero amount of resistance to the reactor getting colonized by opportunistic bacteria (yeast etc), and not attack the one specific cell type that you care about. It's about pushing the requirement for sterility down from 100% to 'only' 99.99%.
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