[cing]

There is innovation in this space. From green chemistry initiatives to replace hazardous solvents by CROs/industry invested in large-scale production of peptides, https://www.bachem.com/news/bachem-novo-nordisk-redesign-spp..., to routine solid-phase synthesis of peptides greater than 100 amino acids in hours (https://www.science.org/doi/10.1126/science.abb2491, being commercialized here https://www.amidetech.com/)

[dnautics]

Lol at the first one, replacing nmp with DMSO/EtOAc while an improvement in toxicity, it's still expensive, toxic, and hard to remove/recycle.