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Moderna has fewer breakthrough cases than Pfizer's, but higher myocarditis rates

53 points| NoRagrets | 4 years ago |cnbc.com | reply

61 comments

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[+] Scoundreller|4 years ago|reply
Not really a surprise, moderna has a much higher dose, mcg for mcg. 100 vs 30.

At least where I am, booster doses using moderna are recommended at half doses (50mcg).

They both use the same spike protein sequence.

No idea how the excipients differ between the two, but neither has adjuvants.

[+] brundolf|4 years ago|reply
Wow I didn't realize that about the dose difference, I wondered why they gave us a half dose for our booster
[+] staticassertion|4 years ago|reply
It's more than 'not really a surprise', it is obvious and I'm pretty sure this had already been widely discussed months ago.
[+] bigodbiel|4 years ago|reply
Meanwhile the mechanism behind peri/myocarditis and why it mainly affects young males is still unknown. Needle aspiration, LNP, spike protein exosome... ? this all being bleeding edge technology and applied at such scale is really is amazing.
[+] kennywinker|4 years ago|reply
Without being applied at massive scale we probably wouldn't even be able to link the two. 13.3 cases of myocarditis per 100,000 (moderna) or 2.7 cases per 100,000 (pfizer) would be very hard to detect if we weren't giving out billions of doses. For perspective, the global before-covid rate of myocarditis was something like 1.5 cases per 100,000.
[+] Tagbert|4 years ago|reply
My understanding is that the incidence of myocarditis is much higher in a COVID infection than from any of the vaccines.
[+] gfosco|4 years ago|reply
Any source available on this?
[+] Mikeb85|4 years ago|reply
But what's the risk profile of Moderna + myocarditis versus Pfizer + breakthrough case (and remember, odds of contracting Covid at all are less than 1) + myocarditis?

Any stats on how many 13-29 year olds vaccinated with Pfizer have gotten myocarditis from a breakthrough case specifically?

[+] vimy|4 years ago|reply
Anecdotal: Had covid twice. No heart complaints.

Had two vaccine shots. Both times, 10 days after the shot, my heart hurt like hell. Really painful and scary experience. It lasted a couple days and back to normal.

[+] tomp|4 years ago|reply
numbers:

> Burton cited data from France on males ages 12 to 29. It showed there were 13.3 cases of myocarditis per 100,000 people for Moderna’s vaccine compared with 2.7 cases per 100,000 people for the Pfizer vaccine.

> there were 86 breakthrough cases per 100,000 people for the Moderna vaccine. That compares to 135 breakthrough cases per 100,000 for Pfizer’s, he said

Are the differences meaningful? Assuming the data is real, Pfizer does seem quite a bit safer!

[+] credit_guy|4 years ago|reply
It's difficult to judge the tradeoff between Covid and myocarditis. I got my Moderna booster shot about 2 weeks ago, and I felt palpitations next day. Was that myocarditis. Maybe. I guess I'll never know. Did it bother me? Very little. I'm quite happy that my immunity to Covid went up. I'll personally trade a few palpitations for good Covid immunity.

But that's just a case of 1. How severe is the myocarditis other people experience? According to a study I just googled [1], out of 2 million people, only 32 were hospitalized with myocarditis or pericarditis, with median hospitalization time of 1 to 2 days, no ICU, and no deaths. Doesn't sound so bad to me.

[1] https://jamanetwork.com/journals/jama/fullarticle/2782900

[+] staticassertion|4 years ago|reply
I wouldn't draw that conclusion. That's a 50% increase in break through cases with Pfizer, which seems like a far greater threat than even a 5x increase of myocarditis.

Especially when you take into account that your risk of developing myocarditis is higher if you get Covid.

[+] exegete|4 years ago|reply
It’s a good question. Is there a statistical test that can be / has been done with the data? Are the numbers between Pfizer and Moderna statistically different (and are they different than the incident rate in the general population)?
[+] bool3max|4 years ago|reply

[deleted]

[+] akmarinov|4 years ago|reply
It’s the part where you say that it provides no benefits - that’s where you’re wrong and your whole argument falls apart.
[+] vmception|4 years ago|reply
higher, but low, but higher

have you seen the new psyop where vaccine holdouts now get the shot but believe they can quickly remove it, similar to reacting to venom? I’ve been starting to think of things like that at their level of comprehension. I’m getting better at it. Will be procedurally generating this benign nonsense soon.

I started noticing someone was already doing it after the prior psyop was so obvious. Many anti vaxxers began believing could only avoid “shedded spike proteins of the vaccinated” by social distancing and masking up forever. Ironically gaining compliance with all guidelines but in a way they believed was original and never having to argue with them ever.

Got to think like them! Similar to what comedians do.

[+] ifyoubuildit|4 years ago|reply
> have you seen the new psyop where vaccine holdouts now get the shot but believe they can quickly remove it, similar to reacting to venom? I’ve been starting to think of things like that at their level of comprehension. I’m getting better at it. Will be procedurally generating this benign nonsense soon.

I'm not saying I agree or disagree with anything you're saying here, but more and more I wish I had some kind of debugger that I could run on internet comments, and it would show me all of the inputs that a commenter saw that led to the comment in question. All the various social media threads, conversations with friends/family/doctors, published papers, news articles, every single input that factored into what was written.

I say this because this comment to me seems like nonsense, because it doesn't line up with any of my inputs. Which of course doesn't mean it actually is nonsense, it just looks that way to me.

I think if we had this capability, people would actually be able to understand each other. Instead we just have everyone thinking that the sum of their own inputs is the ground truth, and everyone else is a nutjob.

[+] narrator|4 years ago|reply
Lots and lots of flagged and deleted posts here. I thought Hacker News was outside of what Eric Weinstein likes to call the Distributed Idea Suppression Complex[1]. That the DISC is deeeeeply troubled by the comments on this story should tell you everything you need to know about this topic. Speaking of which, is there anything like Snoo for reddit that keeps track of deleted and flagged posts on HN?

[1] https://theportal.wiki/wiki/The_Distributed_Idea_Suppression...

[+] staticassertion|4 years ago|reply
There are tons of flagged and deleted posts on every HN thread because there are tons of really bad posters on HN. Honestly I think some of the absolute dumbest things I've ever read on the internet were on this site. Thank god we can flag the really low signal garbage.

> is there anything like Snoo for reddit that keeps track of deleted and flagged posts on HN?

Not for deleted but you can "show dead" in your HN settings.

[+] ahevia|4 years ago|reply
One of the deleted comments was calling HN a breeding ground for conspiracies for sharing an CNBC article? Another was spewing a complaint about having to wear masks.

It isn’t censorship or suppression to delete comments that insult a community and provide nothing constructive to a conversation.

I also don’t care to define what “constructive” is in this context.The HN Mods can handle that.

[+] unethical_ban|4 years ago|reply
>Lots and lots of flagged and deleted posts here.

No there are not. Your account is old enough to have known that there aren't even that many comments at all on this page. IIRC, comments never get deleted, only flagged.

>That the DISC is deeeeeply troubled by the comments on this story should tell you everything you need to know about this topic.

Even accepting your premise of the "DISC" from contrarian podcaster on a wiki with few citations of any claims: No, one little "clue" doesn't tell anyone "everything they need to know" about a topic.

>Speaking of which, is there anything like Snoo for reddit that keeps track of deleted and flagged posts on HN?

I'm not aware of one.

[+] loonster|4 years ago|reply
For popular controversial posts like this, the mods often override the flags and show everything.
[+] vmception|4 years ago|reply
What does it tell us about the topic? That rhetorical comments are inbound?
[+] jbd28|4 years ago|reply
Plenty of independent ideas are also nonsensical