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reindeer76 | 4 years ago
>The mRNA and viral vector vaccines induced ONLY spike protein antibodies in the inoculated test subjects
>In comparison, whole inactivated virus and natural infection induce antibodies to many parts of the virus
Original antigenic sin:
>Subjects injected with the old formulations have locked their immune response to only a few antibodies
>Any new formulation of the injection will amplify those antibodies rather than inducing new ones
Antibody-dependent enhancement:
>Omicron may have mutated to take advantage of non-neutralising antibodies to the injection spike protein
>This would mean that the virus can more easily latch onto the CD147 receptor and enter cells in the vaccinated
fabian2k|4 years ago
The mRNA vaccines also induce the cell-mediated immunity, unlike e.g. subunit vaccines that only consists of a protein. The cell-based response is fundamentally different and not based on the 3D structure of the virus protein like the antibody response. So mutation that would evade the antibody response would not automatically evade the cell-based response as well.
The spike protein is also the most important protein of the virus. And antibodies are mostly useful against surface components of the virus, not so much against stuff that's on the inside. The spike protein performs a critical function, to evade the antibody response it has to do both, change enough to be unrecognizable while still being able to infect cells with a similar efficiency. That's not an easy thing to do.
brandmeyer|4 years ago
Eliezer|4 years ago
There's no edit histories on HN, unless I missed something.
Never forget the windowless buildings in Russia, where people are working to make you hate each other. At least make it harder for them than simple semiautomated tricks like this.
eurasiantiger|4 years ago