[yunesj]

Of 288,072 people aged 16-39, only 6 people who had only 2 doses were hospitalized, compared to 1 person who had 3 doses [1]. This study was published before Omicron in October, for which the vaccine is even less effective and the disease is less severe.

I'm not yet aware of any other study that indicates the booster is useful for people in this age group.

I thought that a spike in antibodies might be useful in the short term, but a recent CDC presentation [2] said of an Omicron case study:

> 79% fully vaccinated; 32% with booster dose; Five of the 14 persons received additional dose <14 days before symptom onset

which doesn't give me any confidence.

> security theatre

Since mandates don't exclude people that were previously infected, to me, they seem punitive.

[1] https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

[2] https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-...

[maxk42]

From the lancet study:

"Vaccine effectiveness evaluated at least 7 days after receipt of the third dose, compared with receiving only two doses at least 5 months ago".

Literally no control for recency. Newer research (admittedly, not yet peer-reviewed) seems to show that efficacy of the vaccines dwindles over time. As little as 90 days. [1]

The results from the booster may have more to do with having received a vaccine more recently than they do with the overall efficacy of any of the vaccines.

https://www.medrxiv.org/content/10.1101/2021.12.20.21267966v...

[yunesj]

Wow, that's not an encouraging paper!

It doesn't just say that "efficacy of the vaccines dwindles over time," but that the 2-dose vaccine effectiveness against omicron is significantly negative in the 91-150 day bucket.