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I tried a pyflow a couple years ago. It was very confusing and not intuitive at all, which is what I think one of the biggest advantages of these types of GUIs is supposed to be. Doing simple things like adding inputs and operations to the graph were very difficult.

I ended up developing my own tool based on the flowchart editor in pyqtgraph. The GUI for that was quite intuitive and the code to modify it was also far simpler. That said there are a few features from pyflow that I wish the pyqtgraph editor had, like subgraphs.