>The mechanism appears to be mediated in part by activation of the IRE1α RNase and interferon pathways.
>Thus, the RNase activity of IRE1α induced by CBD can potentially account both for the degradation of viral RNA and the induction of interferons by the RNA fragments.
"Overall, our study investigates for the first time the effects of the endocannabinoid AEA on primary human T-lymphocytes, demonstrating that it is a powerful modulator of immune cell functions. In particular, not only we clarify that CB2R mediates the immunosuppressive activity of AEA, but we are the first to describe such an immunosuppressive effect on the newly identified Th-17 cells. These findings might be of crucial importance for the rational design of new endocannabinoid-based immunotherapeutic approaches."
The only way CBD can trigger these pathways is by effecting a cell receptor The only cell receptors for CBD are CB1r and CB2R. There is literally no other way this can happen.
If y9ou can explain how CBD increases IRE1α activity any other way I am all ears,
netizen-936824|4 years ago
>The mechanism appears to be mediated in part by activation of the IRE1α RNase and interferon pathways.
>Thus, the RNase activity of IRE1α induced by CBD can potentially account both for the degradation of viral RNA and the induction of interferons by the RNA fragments.
podgaj|4 years ago
https://journals.plos.org/plosone/article?id=10.1371/journal...
"Overall, our study investigates for the first time the effects of the endocannabinoid AEA on primary human T-lymphocytes, demonstrating that it is a powerful modulator of immune cell functions. In particular, not only we clarify that CB2R mediates the immunosuppressive activity of AEA, but we are the first to describe such an immunosuppressive effect on the newly identified Th-17 cells. These findings might be of crucial importance for the rational design of new endocannabinoid-based immunotherapeutic approaches."
The only way CBD can trigger these pathways is by effecting a cell receptor The only cell receptors for CBD are CB1r and CB2R. There is literally no other way this can happen.
If y9ou can explain how CBD increases IRE1α activity any other way I am all ears,