The vaccine antigen is only a small part of the virus. Furthermore is was modified and is inert.
https://cen.acs.org/pharmaceuticals/vaccines/tiny-tweak-behi...
Because of international pharmacovigilance we know that ARNm vaccine induce some myocarditis and pericarditis, at a much lower rate than the virus and less severe.
There is not evidence that heart inflammation after vaccination is less common or severe than after COVID-19 infection. For instance: https://www.medrxiv.org/content/10.1101/2021.12.23.21268276v... suggests rates several fold higher for vaccination than infection. Not to say that on balance vaccination is anything but preferable to naive infection, but it's not a side effect free panacea.
> The free-floating Spike proteins synthetized by cells targeted by vaccine and destroyed by the immune response circulate in the blood and systematically interact with angiotensin converting enzyme 2 (ACE2) receptors expressed by a variety of cells including platelets, thereby promoting ACE2 internalization and degradation. These reactions may ultimately lead to platelet aggregation, thrombosis and inflammation mediated by several mechanisms including platelet ACE2 receptors. Whereas Phase III vaccine trials generally excluded participants with previous immunization, vaccination of huge populations in the real life will inevitably include individuals with preexisting immunity. This might lead to excessively enhanced inflammatory and thrombotic reactions in occasional subjects. Further research is urgently needed in this area.
50% and lower rate (the hk children myocarditis study) isn't a "much lower rate". Factor in omnicron and the clear difference between vaccinating everyone and 10% of society getting the virus and unsolvable questions should begin to arise.
"She says she has preliminary evidence that vaccination can lead to microclots, although in most cases they go unnoticed and quickly disappear—an effect she and a colleague saw in their own blood and that of eight other healthy volunteers, which they sampled after their vaccinations."
The clotting issues would presumably come from the spike protein binding with your ACE2 receptors and downregulating them. Of course it's kind of moot, since empirically we know that getting the vaccine has a hugely positive expected value.
I think this should be researched further. There are countries that are more or less unvaccinated and can serve as a control group. Without that you simply cannot answer the question.
Useless anecdotal evidence from my wife’s hairdresser, she has just been diagnosed with Myocarditis after having a Moderna booster, she thinks it’s linked…
Just to clarify my point here (which has been deservedly down voted), I found it interesting that someone who is fully vaxed (as am I) and believes in the vaccines thinks they may have had a significant adverse effect. I think this shows how people are approaching it. They are excepting of the fact that they may have adverse reaction in incredibly rare cases but understand that the vaccine is needed.
The possibility, albeit incredibly unlikely, of as adverse affect has been accepted by the public as ok.
In her case she actually has some other health concerns that may well turn out to be the cause.
lucd|4 years ago
inciampati|4 years ago
mikevm|4 years ago
> The free-floating Spike proteins synthetized by cells targeted by vaccine and destroyed by the immune response circulate in the blood and systematically interact with angiotensin converting enzyme 2 (ACE2) receptors expressed by a variety of cells including platelets, thereby promoting ACE2 internalization and degradation. These reactions may ultimately lead to platelet aggregation, thrombosis and inflammation mediated by several mechanisms including platelet ACE2 receptors. Whereas Phase III vaccine trials generally excluded participants with previous immunization, vaccination of huge populations in the real life will inevitably include individuals with preexisting immunity. This might lead to excessively enhanced inflammatory and thrombotic reactions in occasional subjects. Further research is urgently needed in this area.
cedivad|4 years ago
Alex3917|4 years ago
The vaccine appears to cause minor damage, but more likely from the spike protein than from the immune response. C.f. this article:
https://www.science.org/content/article/rare-cases-coronavir...
"She says she has preliminary evidence that vaccination can lead to microclots, although in most cases they go unnoticed and quickly disappear—an effect she and a colleague saw in their own blood and that of eight other healthy volunteers, which they sampled after their vaccinations."
The clotting issues would presumably come from the spike protein binding with your ACE2 receptors and downregulating them. Of course it's kind of moot, since empirically we know that getting the vaccine has a hugely positive expected value.
raxxorrax|4 years ago
rsfern|4 years ago
samwillis|4 years ago
Could be linked, probably not.
samwillis|4 years ago
The possibility, albeit incredibly unlikely, of as adverse affect has been accepted by the public as ok.
In her case she actually has some other health concerns that may well turn out to be the cause.
unknown|4 years ago
[deleted]
lima|4 years ago
Like you say, a single data point is useless.
vegai_|4 years ago
WaxedChewbacca|4 years ago
[deleted]
GameOfFrowns|4 years ago
That is quite the assertive statement in the light of all these public cases of vaccinated athletes keeling over. Is this flamebait?