[tcherasaro]

Same, Sudafed is a silver bullet for me. The 12 hour release absolutely works to clear my sinuses and relieves the sinus pressure headache (almost completely when combined with ibuprofen).

My wife insists Phenylephrine works for her and thats all she will take. She has offered it to me a couple times when we didn’t have any Sudafed and Phenylephrine had 0 noticeable effects for me.

Edit: I forgot to add that Alavert-D 12 also has Pseudoephedrine and works for me too and is what I take when my congestion is allergy related.

[mh-]

One of many such studies: https://pubmed.ncbi.nlm.nih.gov/19230461/

Keep in mind this doesn't say that it's not effective. It's just not more so than the placebo effect, which is quite real even on physiological matters.

[thehappypm]

The article suggests the uptake is widely variable person to person so perhaps she’s just a lucky one.