I tried to learn Cython last year, but was thwarted by two issues: (1) its syntax was too ugly for my taste and support for the pure Python mode was immature; (2) performance bottlenecks were opaque and hard to profile (at least for beginners). I ended up picking up Nim, a language with Python-like syntax and C-like performance, and was productive within hours (literally). I never looked back.
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