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RspecMAuthortah | 3 years ago

I had smallpox growing up in a third world country, how protective would the immunity be going against that?

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retrac|3 years ago

Big caveat: we don't actually know, because it hasn't been studied, because human monkeypox is very rare. Still, some conjecture:

You're very probably immune. Recovery from smallpox almost always meant life-long immunity and re-infection was basically unknown when it was common. The orthopoxviruses are known to have a lot of cross-immunity. People who get cowpox are immune to smallpox, and vice versa. The classic smallpox vaccine used widely in the 20th century was just a very mild strain of pox (genetically somewhere between smallpox and cowpox, and of uncertain origin now lost to history) which causes almost no illness in humans.

etiam|3 years ago

As Lowe notes in the blog piece, statements of about 85% protection from the smallpox vaccine are going around.

I haven't seen anything in particular about the protection resulting from a full-blown, non-attenuated infection, but as I understand it from discussions apropos another pathogen of fame lately, the rule of thumb is more comprehensive and lasting immunity from going through the disease as compared to vaccinations.

That is, I believe you ought to be in great shape compared to most of the world population.

What was it like? If it can be meaningfully described...

jonny_eh|3 years ago

Apparently the smallpox vaccine protects against monkeypox, I imagine recovering from one would protect against the other.

mmastrac|3 years ago

Not total but some protection. The last article I read suggested a fully vaxxed person still had a couple of lesions (how it was detected). Definitely better than a full blown attack.