[SemanticStrengh]

> I suspect that my opinion is just as much gibberish as yours clearly is, but with more self-awareness.

OK thank you layman for your ad-hominem, I have extensive expertise in medecine and pharmacology and have extensively studied the thymus, spleen, associated peptides and immune and aging biomarkers, so what seems to you as gibberish is actual valid statements or for a few ones, very reasonable and necessary to be asked speculations. But indeed, an expert is often difficult to distinguish from a bullshitter when the layman lacks discernment, a formation in epistemology nor care to check any of the sourced premises.

> why would that "budget" be "for vaccines" _only_ ?

Well for starters I do not question wether there is a budget limit, there is it is a fact. I even explain in detail that a necessary component in the equation are naive lymphocite T and that aging and environement stressors induce an atrophy (involution/shrinkage) of the thymus and therefore of the total number of differentiated mature lymphocytes T. Also obviously I do not say that this only apply for vaccines, real covid is not much different from the spike protein and in fact induce more damage, however the question has to be asked, regardless.

> consider what answer would have better evolutionary fitness

and yet having a limit is an evolutionary fitness as show the existence of thymus involution, both for reduced energy use and programmed aging evolutionnary benefits as shows the many papers on the topic. Obviously, as you should have guessed, the limit only matter to not be reached before the age of reproduction, which is < 20 years old

[SideburnsOfDoom]

> I have extensive expertise in medecine and pharmacology

a) not present in your comment history - clearly that's not your focus area - and b) not even spelled correctly and c) I do not believe you

> and have extensively studied the thymus, spleen, associated peptides

Uh uh. Heart, liver and associated oligosaccharides. Gotcha. (this is equally irrelevant gibberish when talking about immune system responses)

> I do not say that this only apply for vaccines

Yeah, you do say that, you say "I am wondering how much immune "budget" do humans have for vaccines?"

[antiterra]

12 days is ages ago, but:

While we should always question declarations of expertise without evidence, YCombinator is a place of curiosity and immediately dismissing someone's consideration as gibberish is counter-productive and rude.

> a) not present in your comment history - clearly that's not your focus area - and b) not even spelled correctly and c) I do not believe you

I disagree, there's a significant amount of detailed information in the comment history that suggests this (although I am not vouching for accuracy of any of it.)

> > and have extensively studied the thymus, spleen, associated peptides > Uh uh. Heart, liver and associated oligosaccharides. Gotcha. (this is equally irrelevant gibberish when talking about immune system responses)

Wrong. You didn't even do a web search to check.

The thymus produces immune cells. The spleen generates lymphocytes in response to foreign micro-organisms/viruses. Spleen peptides are used for enhancing immune function after radiation therapy and chemotherapy.

> Yeah, you do say that, you say "I am wondering how much immune "budget" do humans have for vaccines?"

No. Wondering about an immune budget for vaccines does preclude the possibility an immune budget applies to natural immunity.