[netizen-936824]

I would argue that MDMA and methamphetamine, while slightly similar in chemical structure, have very different mechanisms of action. Methamphetamine, at high enough doses. This is why dose is important, some recreational doses will cause dopamine efflux from the dopamine uptake transporter but MDMA does not do this

Doses are incredibly portant when discussing the mechanisms of drugs and comparing them because a compound may interact with new and different proteins when the concentration gets high enough. Recreational doses for methamphetamine and cocaine are all over the place partially due to the fact that you can develop tolerance and increase your dose. This doesn't really happen with MDMA as much, and while you can take repeated doses they will rapidly stop working if taken within a small enough time frame. Methamphetamine and cocaine do not have the same tolerance build up

While cocaine is a triple reuptake inhibitor and does interact with serotonin, I don't think its comparable to MDMA

[netizen-936824]

>Methamphetamine, at high enough doses.

Causes dopamine efflux out of the uptake transporter*