Not in the field, but evidence is strongly stacking behind the notion that lifespan is largely related to energy metabolism. [1]
Larger species tend to have slower metabolisms than smaller species, but larger specimens within a species tend to have faster metabolisms than smaller ones (eg smaller dogs live longer than larger dogs, but larger species such as humans live longer than dogs). It's thought that part of the reason behind this odd relationship, is because there are multiple factors behind energy metabolism. One being a species genetics, another being caloric intake for instance.
It get's further complicated when studying actual cellular pathways used in metabolizing energy (such as AMPK, MTOR). Recent (even Nobel prize winning [2]) research has shown that, these pathways don't just regulate energy metabolism, they also influence cellular/DNA repair [3]. The gist being, there's an inverse relationship, where the body doesn't do well at cleanup/repairing old cells when it's busy metabolizing and building new cells (such as when your eating/growing).
Rury|3 years ago
Larger species tend to have slower metabolisms than smaller species, but larger specimens within a species tend to have faster metabolisms than smaller ones (eg smaller dogs live longer than larger dogs, but larger species such as humans live longer than dogs). It's thought that part of the reason behind this odd relationship, is because there are multiple factors behind energy metabolism. One being a species genetics, another being caloric intake for instance.
It get's further complicated when studying actual cellular pathways used in metabolizing energy (such as AMPK, MTOR). Recent (even Nobel prize winning [2]) research has shown that, these pathways don't just regulate energy metabolism, they also influence cellular/DNA repair [3]. The gist being, there's an inverse relationship, where the body doesn't do well at cleanup/repairing old cells when it's busy metabolizing and building new cells (such as when your eating/growing).
[1] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994661/
[2] - https://www.bluezones.com/2018/10/fasting-for-health-and-lon...
[3] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713320/