[JulianMorrison]

A big part of the problem is things moving so fast that a lot of stuff doesn't have a long run. Covid and its vaccines being an example. In the end the reason to trust them was a mix of "if not this, then what?" and "it doesn't seem to be killing people".

[fabian2k]

We have a lot of really good evidence that the vaccines are preventing a lot of deaths.

[fithisux]

We have excellent evidence that the amyloid hypothesis is valid. Otherwise you get no grant (enter the clothing shop).

This is sarcasm of course.

[ncmncm]

It has been unfortunately necessary to downplay cases of debilitation and, even, death apparently traceable to vaccination. If vaccination saves the lives of a hundred times as many people as it harms, in the "trolley" sense, that should be good enough, but in popular imagination it is not.

Rational treatment might enable identifying individuals particularly at risk and not vaccinating those, but that option is closed to us. Instead, a random, suspicious fraction of the population pays particular attention to negative outcomes and avoids vaccination, to its detriment, and most of those at risk for problems get vaccinated anyway.