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Vitamin D supplementation worsens Alzheimer's progression

39 points| nojs | 3 years ago |onlinelibrary.wiley.com

16 comments

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[+] ekianjo|3 years ago|reply
In Alzheimer mice models, which are completely flawed to begin with. Another pure junk headline.

They also did a retrospective population-based cohort study (no intervention), which is not enough to prove any kind of causality and is prone to confounding factors that can't be easily controlled for (how much time people spend in the sun every day will have a huge impact in their Vitamin D levels and their needs for supplementation or not).

[+] robwwilliams|3 years ago|reply
You may well be right.

But there are good and bad mouse models of early onset Alzheimer’s.

The best is the AD-BXD mouse family model of C. Kaczorowski and colleagues. This “model” is genetically diverse—like humans.

[+] cc101|3 years ago|reply
I'm 76. Have declining cognitive function. Have been taking D3 for over a decade. Damn! I don't know what to do other than to experiment with not taking D3.
[+] JPLeRouzic|3 years ago|reply
I am 65.

20 years ago I am pretty sure I had declining cognitive functions. At the time I was a good research engineer, but actually I was morbidly obese, was unable to walk 2km (~1.2 miles).

Yet now I think I am better. What changed? I retired, move to an home in a nice rural setting and tried to improve my health through exercise and loosing weight.

I was not easy but I am now able to walk 20km (13 miles) (I even did a 33km round trip). I didn't regain ability to run more than one hundred yards though.

Another thing is try to improve your cardiovascular health, a stroke is something devastating.

Good luck!

[+] fithisux|3 years ago|reply
Stop eating after 17:00-18:00 pm. If you need to eat, try a banana or a carrot, drink some wine or a beer. Walk a lot, read books or online books a lot.

It may or may not work but this was the best advice from a cardiologist when I was 38.

[+] robwwilliams|3 years ago|reply
Try 2-3 gm of niacinamide (non-flushing Vit B3).

This vitamin keeps mitochondria happy.

Start slowly (1 gm/day) and after a month or two ramp up if all is good to 3 gm/day.

[+] himinlomax|3 years ago|reply
Are you a mouse? In that case, you should indeed be worried. If not, just carry on doing what you've been doing.
[+] flowcont|3 years ago|reply
In a reddit thread I read about the link between the gut biome and different diseases. Someone commented about custom probiotics and that they had seen improvements. They were in the US and they had used flore (I have no idea about them). I think it's worth a try.
[+] ekianjo|3 years ago|reply
> Have been taking D3 for over a decade.

Don't take junk headlines at face value. The paper is not very convincing.