[danielgomari]

> Given the possibility that some findings might lead to the need for medication, are you going to have MDs or PAs or whoever on staff who can prescribe those?

Yes, for when we enter the diagnostics phase of our tests, we will be working with MDs and PAs who can prescribe medication.

> For metabolites found in very low concentrations where draw-to-draw variance is high, how do you deal with that when a person is only sending you one sample at a time?

We will have a reference cohort in place to which your measurements will be compared. Thus, even for a single measurement, we can make statements about values that are out of range. The most benefit will come from longitudinal sampling, where we can see how your blood metabolite levels move over time.

> Is there ever going to be any effort to have this payable by health insurance?

Yes, it’s on our roadmap. We’re also now working on having our tests HSA/FSA eligible.

> Are you doing anything with the feedback data? As in, someone sends you a sample, you tell them to make a behavioral change, does your advice change if future samples don't show a positive intervention effect? How do you know if patients comply with your recommendations?

We are. And you’re exactly on point in that if the interventions have 0 effects on a person, it will be omitted in subsequent reports. Though, we usually see effects on the metabolome with interventions and it becomes a matter of adjusting them. Which ties into our recommendations getting better and better for a person as they continue testing and acting on those recommendations. In terms of how we know if a person complies with recommendations, based on our database, we know of metabolic patterns that would indicate compliance,

> Are you going to offer genetic testing so, say, someone with high LDL or whatever can know if that's due to diet or they just lost the genetic lottery and nothing but statins can possibly help them?

Currently not, but one feature that we will be implementing soon would be the ability to upload genetic information and we’ll integrate that into our analysis.

> I think LDL is not a metabolite but since your "what's measured" page ends with "more published below" and then there is nothing below, I'm not sure what the full extent is of what you're testing for.

We were not sure where LDL was coming from here? Regarding our webpage, the “more published below” refers to the Nature Medicine paper, we cite further down on the page. https://www.nature.com/articles/s41591-021-01266-0

> If not LDL, presumably something you're testing for can have many sources, including genetic propensity, diet, and other environmental factors. How do you determine which of those is most causally relevant before prescribing an intervention?

That’s a good question and will be decided case by case. As an example, if your glucose levels are elevated and you have diabetes, it doesn't really matter why that happened, the consequences are the same. But indeed, there are special cases especially of genetic variants that need special attention. We will work on those and present the data accordingly in the reports.