[frankenst1]

Can somebody who knows statistics explain something for me?

They report (https://www.nature.com/articles/s41588-022-01285-8/tables/1, https://doi.org/10.1038/s41588-022-01285-8) e.g. the C allele of rs114142727 to have an OR of 1.285, yet they also report the frequency of said allele to be similar in the case and control group (both ~0.988). Is this a rounding issue (i.e. frequency in the case group must always be higher to report an OR>1) and the frequency is only slightly higher in the case group and the OR becomes so large simply because of the large sampling size? (40K case, 200K controls)

When they report 1.285 OR with a standard error of 0.04 at N=38691, does this roughly translate to a 95% CI of [1.207,1.363]?

[farresito]

I think it's a copy paste error. The minor allele frequency of rs114142727 is around 1%.

[frankenst1]

The reported frequency is with respect to A1, which in this case appears to be the major allele C. According to https://www.ncbi.nlm.nih.gov/snp/?term=rs114142727, the minor allele is G with MAF (ALFA) ~0.013, this would make C the major allele with frequency of ~0.987 which seem to be in line with the report.