As Campbell asked, why has it been left to Danish researchers (who were doing Hepatitis C testing and decided to tack on an assay for covid jab mod-spike mRNA) to look into these questions? Why haven't Moderna or Pfizer undertaken large-scale studies of this type? Why haven't they been mandated by large regulatory agencies in the USA, UK, et al.; Japan; etc.? Why haven't well-funded researchers in those nations done similar work?
We're so far downstream from the initial rollout that nobody seems to recall the blanket assurances that all of the mRNA in the shots would be taken up and translated into modified spike proteins in a very short period given by health authorities and putative experts during the height of the coercion campaigns.
It's much the same as with the issue of biodistribution. Most have forgotten why we were promised the contents of one of these shots remained at the injection site and how the practice of aspiration of the needle (done in Denmark, after concerns were raised, but rarely done elsewhere) was pooh-poohed. The same individuals and entities preached the stays-in-the-arm gospel and derided anyone who raised concern or produced research results indicating wider distribution, via the vasculature, throughout recipients' bodies.
The same people who promulgate the idea that VAERS and the Yellow Card system and analogous institutions are now honeypots for fake reports from Russian bots or the "Science Truster' bogeyman du jour.
Oh well. Spilled milk at this point. The revelations will continue to trickle out for the foreseeable future. Turnover in the upper echelons of regulatory and funding bodies and in academic biomed research will gradually loosen more tongues. Eventually, there may be large lawsuits and settlements. We will see.
I'm no medical professional but this seems like a bit of an over reaction given the article. The article doesn't make mention if there is anything particularly negative about this. More focuses on the behavior of the mRNA after a given time.
I imagine to know something like that would be useful for later itterarations or variations of mRNA applications?
Your comment raises two main straw-men. Neither of which seem to be supported by facts.
What stay-in-the-arms gospel are you talking about?
What reason do you have, besides Campbell's baseless assertion, that such large-scale studies of nucleic acid persistence has not been performed?
Because they know already. Many patient died from these jab DIRECTLY. But of course everyone must ignored it. You can see many medical researchers hesitant to research on this topics let alone getting published and then peer-reviewed. Personally I've known people dying DIRECTLY of the jab within 2 days of it. And I know many knowing someone died and not hearing from someone else someone else story. And yet, here even medical doctors have been cautioned not to speak about it or will face consequences not only from pro-vac group but government or medical board displine. So at this point, we will just have to keep it quiet until #1 a lot of people been affected like thalidomide years ago, or #2 nothing happens, and those did died are just collateral damages.
The article mentions they ran the study from May until June, and detected mRNA 28 days after administration... I didn't see mentioned if the test period expired or if they stopped because it became undetectable. I wonder if it can be detected longer if they measured longer?
The more worrying thing here is the "circulate" part. Meaning that the lipid packages containing the mRNA sequences are traveling throughout the body, instead of staying at the injection site.
It's probably neither a good or a bad thing, it's just a "we found something that may guide our future understanding of how mRNA vaccines work". Sounds like basic research that has no direct implications.
Interesting. It seems like the mRNA itself breaks down in most cases like expected, but sometimes the particles/packages that contain the mRNA don't ever get opened, meaning the mRNA is never processed or exposed to the body.
2022-03-17: “Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination”
> “Prolonged detection of vaccine mRNA in LN GCs [lymph node germinal center https://en.wikipedia.org/wiki/Germinal_center] and spike antigen in LN GCs and blood following SARS-CoV-2 mRNA vaccination”
> “Immunohistochemical staining for spike antigen in mRNA-vaccinated patient LNs varied between individuals but showed abundant spike protein in GCs 16 days post-second dose, with spike antigen still present as late as 60 days post-second dose. ”
2022-06-28: “Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination”
> “A recent ultrasensitive single-molecule assay was however able to detect the S-protein in the plasma of some mRNA-1273 COVID-19 vaccinees at 15 days following injection [12], while in another study, both mRNA and S-protein could be found in axillary LNs after 60 days [13]. Moreover, extracellular vesicles decorated with S-proteins persist up to 4 months after vaccination with BNT162b2 [14]. This raises the possibility that LNP–mRNA complexes remain in circulation for extended periods of time, retaining their ability to induce S-protein expression in contacted cells.”
> “In plasma, mRNA was immediately detectable at just hours following vaccination, remained detectable when sampled at 6 and 15 days (Figure 1A, green), but was below the limit of quantification (LoQ) for one sample at 27 days. Samples from negative controls did not amplify. For subject B3, we observed a similar trend for plasma: vaccine-associated mRNA became detectable immediately after vaccination and remained significantly above the LoQ at day 14 (Figure 1B, green). Interestingly, vaccine mRNA was detected in the cellular fraction up to day 6 in some samples from our cohort, whereas for B3, it was only detectable at one day after vaccination (Figure 1A,B, orange). It has to be noted that the likelihood of detecting vaccine mRNA in the cellular fraction decreased significantly at 24 h from injection, which was in contrast to plasma in which mRNA remained consistently detectable up to day 15 (Figure 1C).”
> “mRNA vaccines use mRNA created in a laboratory to teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies. The mRNA from the vaccines is broken down within a few days after vaccination and discarded from the body.”
This post, a link to a peer-reviewed paper published in mid-January 2023 ("SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination"), has been flagged.
This action is typical of the efforts, top-down and bottom-up, to suppress open discussion of the risks and the harm and suffering caused by many aspects of the responses to covid-19.
To the flaggers: you are abusing this site's flagging functionality, most probably in an attempt to prevent the dissemination of valid scientific research that has a real bearing on public health decision-making. Your behavior is disgraceful.
I realize it's frustrating when a story is flagged which you consider on-topic, but please don't call names ("your behavior is disgraceful") post in the flamewar style to HN. It only makes things worse.
[+] [-] briandon|3 years ago|reply
We're so far downstream from the initial rollout that nobody seems to recall the blanket assurances that all of the mRNA in the shots would be taken up and translated into modified spike proteins in a very short period given by health authorities and putative experts during the height of the coercion campaigns.
It's much the same as with the issue of biodistribution. Most have forgotten why we were promised the contents of one of these shots remained at the injection site and how the practice of aspiration of the needle (done in Denmark, after concerns were raised, but rarely done elsewhere) was pooh-poohed. The same individuals and entities preached the stays-in-the-arm gospel and derided anyone who raised concern or produced research results indicating wider distribution, via the vasculature, throughout recipients' bodies.
The same people who promulgate the idea that VAERS and the Yellow Card system and analogous institutions are now honeypots for fake reports from Russian bots or the "Science Truster' bogeyman du jour.
Oh well. Spilled milk at this point. The revelations will continue to trickle out for the foreseeable future. Turnover in the upper echelons of regulatory and funding bodies and in academic biomed research will gradually loosen more tongues. Eventually, there may be large lawsuits and settlements. We will see.
[+] [-] bilekas|3 years ago|reply
I imagine to know something like that would be useful for later itterarations or variations of mRNA applications?
[+] [-] hcknwscommenter|3 years ago|reply
What stay-in-the-arms gospel are you talking about? What reason do you have, besides Campbell's baseless assertion, that such large-scale studies of nucleic acid persistence has not been performed?
[+] [-] jjtheblunt|3 years ago|reply
[+] [-] sander27home|3 years ago|reply
[+] [-] Femoloto|3 years ago|reply
[deleted]
[+] [-] decremental|3 years ago|reply
[deleted]
[+] [-] GenerocUsername|3 years ago|reply
[+] [-] Baloo|3 years ago|reply
[+] [-] wolfium3|3 years ago|reply
(Please correct me in the thread if my understanding is incorrect)
[+] [-] collias|3 years ago|reply
[+] [-] hannob|3 years ago|reply
[+] [-] yeahbutiguess|3 years ago|reply
[+] [-] AlbertoGP|3 years ago|reply
2022-03-17: “Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination”
> “Prolonged detection of vaccine mRNA in LN GCs [lymph node germinal center https://en.wikipedia.org/wiki/Germinal_center] and spike antigen in LN GCs and blood following SARS-CoV-2 mRNA vaccination”
> “Immunohistochemical staining for spike antigen in mRNA-vaccinated patient LNs varied between individuals but showed abundant spike protein in GCs 16 days post-second dose, with spike antigen still present as late as 60 days post-second dose. ”
https://www.cell.com/cell/fulltext/S0092-8674%2822%2900076-9
2022-06-28: “Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination”
> “A recent ultrasensitive single-molecule assay was however able to detect the S-protein in the plasma of some mRNA-1273 COVID-19 vaccinees at 15 days following injection [12], while in another study, both mRNA and S-protein could be found in axillary LNs after 60 days [13]. Moreover, extracellular vesicles decorated with S-proteins persist up to 4 months after vaccination with BNT162b2 [14]. This raises the possibility that LNP–mRNA complexes remain in circulation for extended periods of time, retaining their ability to induce S-protein expression in contacted cells.”
> “In plasma, mRNA was immediately detectable at just hours following vaccination, remained detectable when sampled at 6 and 15 days (Figure 1A, green), but was below the limit of quantification (LoQ) for one sample at 27 days. Samples from negative controls did not amplify. For subject B3, we observed a similar trend for plasma: vaccine-associated mRNA became detectable immediately after vaccination and remained significantly above the LoQ at day 14 (Figure 1B, green). Interestingly, vaccine mRNA was detected in the cellular fraction up to day 6 in some samples from our cohort, whereas for B3, it was only detectable at one day after vaccination (Figure 1A,B, orange). It has to be noted that the likelihood of detecting vaccine mRNA in the cellular fraction decreased significantly at 24 h from injection, which was in contrast to plasma in which mRNA remained consistently detectable up to day 15 (Figure 1C).”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313234/#
The CDC for instance states in its website:
> “mRNA vaccines use mRNA created in a laboratory to teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies. The mRNA from the vaccines is broken down within a few days after vaccination and discarded from the body.”
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different...
[+] [-] briandon|3 years ago|reply
This action is typical of the efforts, top-down and bottom-up, to suppress open discussion of the risks and the harm and suffering caused by many aspects of the responses to covid-19.
To the flaggers: you are abusing this site's flagging functionality, most probably in an attempt to prevent the dissemination of valid scientific research that has a real bearing on public health decision-making. Your behavior is disgraceful.
[+] [-] dang|3 years ago|reply
I realize it's frustrating when a story is flagged which you consider on-topic, but please don't call names ("your behavior is disgraceful") post in the flamewar style to HN. It only makes things worse.
https://news.ycombinator.com/newsguidelines.html
[+] [-] vfclists|3 years ago|reply
[deleted]