The more worrying thing here is the "circulate" part. Meaning that the lipid packages containing the mRNA sequences are traveling throughout the body, instead of staying at the injection site.
"When mRNA-LNPs were injected intramuscularly and intratracheally, similar to intravenous and intraperitoneal deliveries, a large portion of the luciferase activity was detectable in the liver, demonstrating systemic spread of the nanoparticles."
Yes, and people like Bret Weinstein say this is a massive problem and why there’s heart inflammation, if the mrna enters heart muscle your immune system might well attack it, the problem is - heart muscle does not get remade.
The mRNA-based covid shots (and the adenovirus-vector covid shots) are a wee bit different in how they operate than pre-covid vaccines.
Modified covid spike proteins are produced by host (i.e. a vaccinee's) cells. The spike proteins are anchored within the cells but "poke out" through the cellular membranes so they're able to elicit an immune system response.
The cells expressing the mod-spike are ultimately destroyed. If you review pop-sci / marketing materials produced by Pfizer and Moderna and government agencies and non-profits who promoted the shots, the fate of these cells will be glossed over, but that's what happens.
This is why it was important that the contents of the jabs stayed in the muscle tissue near the injection site and the process of translating all of the vax mRNA into mod-spike be rapid. If vax mRNA travelled around via the circulatory system and was taken up by cells in, say, the walls of blood vessels throughout the body or cells in the heart or pericardium or in other tissues, then some cells in those locales would be destroyed and, if enough cells in the wrong place at the wrong time were destroyed this way, bad things could happen. Observing vax mRNA persisting or existing weeks and weeks post-administration is not good for this (and additional) reasons.
mlyle|3 years ago
We've known that forever. There's been studies done with luciferase to see where the mRNA triggers protein production in small animals.
We know that a big portion of the activity is in the liver, distant from the IM injection site (a lot of the activity is at the site, too).
e.g. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624045/
"When mRNA-LNPs were injected intramuscularly and intratracheally, similar to intravenous and intraperitoneal deliveries, a large portion of the luciferase activity was detectable in the liver, demonstrating systemic spread of the nanoparticles."
zpeti|3 years ago
vincnetas|3 years ago
briandon|3 years ago
Modified covid spike proteins are produced by host (i.e. a vaccinee's) cells. The spike proteins are anchored within the cells but "poke out" through the cellular membranes so they're able to elicit an immune system response.
The cells expressing the mod-spike are ultimately destroyed. If you review pop-sci / marketing materials produced by Pfizer and Moderna and government agencies and non-profits who promoted the shots, the fate of these cells will be glossed over, but that's what happens.
This is why it was important that the contents of the jabs stayed in the muscle tissue near the injection site and the process of translating all of the vax mRNA into mod-spike be rapid. If vax mRNA travelled around via the circulatory system and was taken up by cells in, say, the walls of blood vessels throughout the body or cells in the heart or pericardium or in other tissues, then some cells in those locales would be destroyed and, if enough cells in the wrong place at the wrong time were destroyed this way, bad things could happen. Observing vax mRNA persisting or existing weeks and weeks post-administration is not good for this (and additional) reasons.
ekianjo|3 years ago
when you do an intramuscular or subcutaneous injection you don't end up in the blood stream typically