I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself to keep drinking, say if my good friends are in town and we’re going out all night? Sure, but there’s some reward center that’s no longer lighting up. I just get drunker, but it’s not more pleasurable. I was never a big drinker at home by myself. Maybe a glass of wine or two with dinner if my in-laws are coming over. Now I’ve literally had zero drinks at home by myself. Seems to have started changing about 3 month in.
Work also seems more interesting, but my untreated ADHD seems to be getting worse.
>I feel great and my brain seems to be functioning as well as when I was in my 20’s
>but my untreated ADHD seems to be getting worse.
I had very similar results after taking ketamine for treatment-resistant depression. It eliminated all my compulsive tendencies for getting cheap dopamine hits (food, doomscrolling, etc), reset my tolerance to everything (caffeine, ADHD meds, alcohol), and made my ADHD worse while improving throughput and ability to Get Shit Done.
I wonder if they affect the same parts of the brain in a roundabout way? Ketamine is also used to treat addiction (opioids, primarily).
Do you experience any anhedonia while using Mounjaro? Did your overall pleasure response get blunted?
I started taking it in November and I’m down 30 pounds and my retina has detached 2x for no apparent reason since then. My drinking is unchanged, except I get full sooner and drink slower. Because of the discomfort.
Good job, nice to see it works on reducing alcohol consumption too. I do not need this drug but it's nice knowing the option exists it need be. It gives hope to others too.
If you're interested - not pushing an agenda. Here's what worked for this weird dude to not drink and stay fit.
I used to lift and be real fit till about 40. Like bulky-lean looking, bench 400 10x with a 6pack. Had a lot to do with being on the road for work all over the world, and you sit at the gym at the hotel for an hour every night because of nothing else to do, and there are girls there also on business who you'll never see again. I drank A Lot, ate anything I wanted, and did lots of blo on weekends.
It was getting out of control, so I did months of google-foo, went to a pharmacy in eastern europe, got like a thousand 150mg disulfiram pills under the counter for fifty bucks, and took one pill every morning for 2 years. You don't drink, you can't drink or you die, you forget drinking exists and after a couple of months don't even think about it, yet still do all the same stuff you used to - like dancing and clubs if that's your thing. And it's even more fun. There were no side effects.
Then things changed with age, testosterone went to crap, joints hurt. I got married and settled down. Can't work out too much now - just a couple of hours per week, and no heavy weights. Within 2 years I couldn't fit into my clothes and had high blood pressure and high cholesterol.
I realized I don't eat because I'm hungry, but because it keeps away sadness. So I changed my diet so I could eat however much I want. I now have a 4-pack instead of 6, fit into my pants, and eat however much I want.
I cut out fat completely. No oil when I cook besides a light spray on the frying pan. No nuts. Tuna - not salmon. Real expensive lean filet if I want cow in my mouth. Only white meat from birds. All the pasta, rice, and potatoes I want, but zero sugar added to anything. Lots of splenda and sweet n low. Fat free fairlife milk (lactose filtered out = less sugar calories). I eat normal sized meals.
Then, I have fruit and berries, and I eat as much of that as I want. I'm stuffing my face the whole day. Today, I had a pint of blueberries, 5 medium apples, 2 mangoes, and a pound of grapes.
Speaking of gastrointestinal issues, my poo is now soft and gentle, and smells delicious.
the most surprising thing to me is how you’re describing normal behavior that I can relate to all my life, but the community of strugglers is so big that this is a whole testimonial people feel comfortable and exalted to share
like thats not something I’m deriding its just news to me
makes me wonder what this drug actually does, flush gut bacteria? just the right ones?
I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly.
The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energy and has developed issues with her bladder, circulatory system, joints, thyroid, and digestive system since starting Ozempic. I’m not saying it’s due to Ozempic, but I am saying all these issues have cropped up in the few months since she started taking it, and she never had any chronic health issues prior. At least she lost some weight, I guess.
As a counter-counter-point I've read most (~90%) of the papers that come out of trials registered at http://clinicaltrials.gov/ for all GLP-1 agonists, including ones that haven't been approved. The vast, vast, vast majority of secondary outcomes, for things like
- blood pressure
- lipids (HDL, LDL)
- insulin sensitivity
- blood glucose
- strokes
- cardiovascular events + deaths
- myocardial infarctions
- hemoglobin A1C,
- revascularization,
- etc, etc, etc
are literally all affected positively (to the benefit of the imaginary "mean" patient) in bulk.
Note though, that doesn't mean 100% of patients are have positive results, just that each of these are, in bulk, positive across the tested subjects when averaged together. There's little in the data to suggest that cases like your family member aren't happening or couldn't happen.
There's also evidence that GLP-1 agonists increase the rate of glucose use in the brain, accelerating learning rates. (The brain accounts for 2% of body weight but up to 25% of glucose consumption, it really is fueled by glucose)
Your relative’s sad story reminds me of a short story I read a few years ago about a miracle pill that leaves about 90% of its takers perfectly slim and able to stay that way eating anything, after a few truly disgusting initial days of elimination, but kills the other 10% gruesomely.
Because it’s so wonderfully effective for the majority, there ends up being a ton of social and economic pressure for anyone even slightly overweight to take it, despite said 10% risk of death.
About 6 months ago there was a posting about Ozempic and I had said something to the effect that it wasn't worth it watching some of the side effects my wife had from it. And then I went to the doctor for a check-up and lo and behold I had diabetes. Asymptomatic, but an A1C of 11. My doctor re-ran the test because he didn't believe it and it doesn't run in my family. My cholesterol had also jumped and he said he was going to put me on a statin after the initial 3 months of adjusting to the diabetes medication.
My Dr. puts me on Ozempic and I grumble about it but with that test results I had, I knew I had to do something. Fast forward 3 months, I dropped 20 pounds, and every other measurement is back in the green, including my A1C. Now, I made some serious lifestyle changes and ate a diabetic diet (limiting carbs, the types of carbs, etc), and have been keeping up with being more active but my entire relationship with food has changed because of Ozempic. Before I had a near compulsion to eat more than I should. Now, I don't because one, I feel fuller quicker and two, I know I'll feel horrible for hours if I over-eat. It only took one of those events to never want to do that again. I can't really explain why but I also don't have as strong of a desire to eat foods that are bad for me. I really thought I'd battle the cravings more after going cold turkey from "bad" foods. I can't say why it is but it's true. Side note, going to the grocery story was really difficult at first....there is so much sugar in the American food supply.
Energy wise I will say that I did struggle with low energy initially as my body adapted to lower calorie intake but I also learned that when I found the right balance of protein/complex carbs for me that my energy levels came back up and I now feel better than ever.
My doctor was shocked. I've never seen him that animated when I came back in for the 3 month follow-up. I didn't need to add any additional medications and they're slowly adjusting me back towards a single medication.
As a counterpoint, I've been using it for several months and have had no side effects to speak of other than occasionally some mild reflux.
If anything, my energy levels actually went up immediately after starting it. Normally I was pretty sluggish but it felt like some extra firepower was unlocked.
Everything has risks and benefits, and might harm some people. I hope your family member gets better soon.
I take it, and when I started I got violently nauseous and had GI issues. I wasn't informed I needed to slowly ramp up.
I still have pretty big appetite suppression, and only minimal nausea sometimes if I eat too much, but what it's done to my blood glucose is AMAZING. And I lost some weight when I started which was a great bonus. It can be hard to start but it's truly worth it, just adjust the dose. I take 0.5mg as I can't handle the larger 1.0mg dose.
The risk of pancreatitis is also increased substantially [0]. And for people who may already be predisposed to pancreatitis but haven’t had an attack, severe pancreatitis has a 10-30% mortality rate [1]. But even mild acute pancreatitis will make you want to crawl out of your own skin in pain.
Reminds me of the first FDA approved weight loss drug, Alli, that basically just gastrointestinally punishes you if you eat more than a few grams of fat.
Yeah, that's definitely always been my challenge with weight loss. I have zero problem with self control -- I can easily cut calories in half or less (e.g. 1000-1200 cal/day), but it's simply that my body suffers immensely. I lose all energy, can't concentrate on anything, and my immune system weakens so I start getting colds constantly.
I'm sure I'd easily lose weight with Ozempic but I'd still be suffering health issues. Not because of Ozempic itself but just because I wouldn't be getting enough calories, despite still being above a healthy weight.
I started Wegovy about 5 months ago. The first couple months you feel sick but after it passes your appetite is extremely curbed (in a good way). Would highly recommend people to try it as it's made me healthier in pretty much every way.
I know this isn't your family member, but if they were a 500-pound alcoholic smoking two packs of cigarettes a day, I suspect they probably felt like crap before the ozempic.
It’s interesting to me how much of the hostility to this drug has a moral dimension. I am quite fit for my middle age. It’s a relative superpower which confers a degree of status in this world. It’s not why I originally became fit 5 or so years ago but it’s something I increasingly notice or to be clear others notice and comment on.
I think the “fit” of the world get inherently uncomfortable that our relative social currency is being “devalued” if everyone can be like us with an “unearned” pill. And it comes out as hostility and skepticism.
I admit haven’t done much research on this particular topic. History should caution us that serious medication like this often has serious side effects which are not apparent early on. I get that. But unlike many others I don’t “hope” that happens like some kind of moral balancing. I get that reaction. In my gut I have that “I did it with willpower and lifestyle and sweat and these people shouldn’t just get it at CVS.” But that’s just the primate status brain talking.
Not that it impacts the outcome but I sincerely hope these drugs can improve people’s lives without significant negative problems. I can find my relative status elsewhere or better yet try to grow up past such impulses.
Well said. I believe you are right. That and ignorance of how Leptin works, setpoint or lipostat theory of bodyweight regulation...once you've gotten fat, your setpoint goes up and the hunger signals are far greater than folks who have never gotten fat. You can have 2 athletes with identical weight height and BF%, but if one had been fat once, their hunger signals from the brain will be far greater than the athlete who was always slim.
Those of us that work out, however, have been dealing with 'cheating with drugs' for a while: steroids. When you get close with enough gym rats, it's utterly shocking how many people with a muscular build use steroids. It's to the point where I essentially don't believe anyone claiming 'natty' (natural) status if they have more than a 1 sigma increase in musculature.
It's also downright laughable how the media/Youtube influencers/etc. treat everyone like idiots. Men's Health will run an article on Mr. Moviestar who was 5'11' and 150 pounds before his role as Superhero Character got to 200 pounds and veiny biceps in 6 months by eating eggs, oatmeal, and chicken breast and doing some situps.
Yes. On a compounded semaglutide. I can finally control my hunger and a nice unexpected effect has been losing a desire to drink large quantities of alcohol. I don’t drink during the week anyway, but it seems to be the volume that turns me off to drinking. Thus a few cocktails are all I can tolerate. For context, Im 30, male, would be defined as a binge drinker on weekends. Oh, and I’ve given up nicotine entirely. I can’t tell if the drug is helping or it was just a point in my life that I finally decided I accept it makes me feel ill most of the time.
I'd hazard a guess that nicotine is one of the two or three most addictive substances known to humanity. Opiates/heroin is probably worse, world of warcraft is probably third :-)
Nicotine was the hardest thing I have ever given up - three years later and I still get the occasional craving or dream where I have an excuse to smoke. This tracks with the experience of other smokes I have known. All else being equal and given you have reason to believe the drug reduces cravings, I'd guess that it is a strong factor
A drug that promotes weight loss, lessens the desire to smoke, drink, etc...sounds too good to be true?
From what I have heard, all of these issues come back as soon as someone comes off the drug. So either a person is committing to a lifetime of being dependent on this drug, or a person is committing to some period of time of ideal living, followed by a possible time of depression after reverting to the status quo.
What happens when you reach your target weight with drugs like this?
After having learned potentionally nothing about nutrition, exercise, and self-control, are you stuck on these meds for life out of fear of binge-eating back to your original weight?
FWIW I'm on a hundred-pound roller coaster ride from 300lbs to 200lbs; currently ~215. I've learned a lot about discipline and sustainable habits along the way.
How long is the research info ozempic and other hormonal weight loss drugs? Remember the last miracle drug that went to the market for weight loss had to be retracted for killing people or damaging their hearts to the tune of over 10 billion dollars in damages paid out.
I tried Ozempic for two months but wasn't able to continue - the gastrointestinal side effects are unbearable. I can confirm lack of desire to eat and drink alcohol. The hunger didn't go away but after a few bites of anything it quickly evaporated. After dropping the drug the hunger steeply increased, even higher than before, that was hard to contain.
the genetics of obesity are amazing.
we all have a unique combination of genes, and epigenic features that influece the endocrine and neuronal pathways that drive the desire to eat, these different genotypes affect our behaviour. Ozempic is putting a thumb on the scales of this pathway, but this pathway is balanced differently in all of us.
Think of the most hungry you have ever been, in some people this never stops, in others it's dialed up or down.
there are some great papers on fat labradors that hint at how these different genotypes are linked to our desire to eat and how that shifts our behaiour.
Guide dogs are highly selected for trainability, and positive reinforcement with food reward plays an important role in their training.
I think it was Yeo, found 22% of pet Labradors and 80% of Labrador guide dogs sampled carried a 14 BP deletion in the POMC gene, which forms part of this pathway.
I was always of the opinion that being fat was a moral failing. Trying the drug really changed that.
Normies have it so easy. They take one bite and feel full. My brain would scream at me continuously to try and make me eat and would never be satisfied.
I was about to get on semaglutide and after extensive research I thought "wait, the results won't be much better than the periods of IF I've had in the past, and the reported benefits are similar", and without side effects. Dropping 30 pounds in 3 months? easy to achieve with the Warrior Diet or OMAD versions of IF.
The results are exactly the same... you fill full eating less quantity, cravings disappear after 1-2 weeks, increased focus and enhanced mental state. But yeah, you need some self-discipline, tons of coffee/matcha and water.
I've concluded that semaglutide is not for me. Just like self-discipline in pills, with potential side effects. So better to give IF another go... I'm in the 4th week and dropped 10lbs already.
I am taking Contrave to lose weight. Lost 30 lbs in 4 months. It is a drug that's composed of an anti-depressant and an opioid antagonist. Together they have a synergistic effect that represses binging envy and cuts appetite.
It also has a repressive effect on drinking and smoke, to my great surprise. And it also has had an effect on my addiction to video games.
Drugs companies get a lot of slack (most of the time deserving) but sometimes they create miracles pills.
it's funny in that a few years ago we were (and still are) excited by the potential cellular protective properties of GLP1 agonists, not just in the pancreas but in brain glial cells or whatnot. So much so that it seems to be the most neuroprotective of recent candidates for Parkinson's disease disease-modifying-therapies (DMTs).
to whit, (like botox), all the initial promises of the stuff have been waaaay overshadowed by...cosmetic value.
(I'm oversimplifying a bit...for those who are morbidly obese, yes, the weight loss really helps, but then they also have diabetes most likely which is the primary indication of the drug)
edit: many point out calorie intake is the real problem, it's true: buy a kitchen scale, weigh your food, count your calories, and you will lose weight. Exercise is optional compared to that. Still, both are free and have more benefits.
From my experience of addiction, suppressing the sensation of pleasure derived, is only the start.
People who are addicted will repeat the behaviour even without the neurochemical response. Consider the ritual of the addiction as a form of self-soothing.
You have to treat the patterns we've trod in our own minds, as well as removing that biological reinforcement.
[+] [-] jmpman|2 years ago|reply
Work also seems more interesting, but my untreated ADHD seems to be getting worse.
[+] [-] CapstanRoller|2 years ago|reply
>but my untreated ADHD seems to be getting worse.
I had very similar results after taking ketamine for treatment-resistant depression. It eliminated all my compulsive tendencies for getting cheap dopamine hits (food, doomscrolling, etc), reset my tolerance to everything (caffeine, ADHD meds, alcohol), and made my ADHD worse while improving throughput and ability to Get Shit Done.
I wonder if they affect the same parts of the brain in a roundabout way? Ketamine is also used to treat addiction (opioids, primarily).
Do you experience any anhedonia while using Mounjaro? Did your overall pleasure response get blunted?
[+] [-] rblatz|2 years ago|reply
[+] [-] helsinkiandrew|2 years ago|reply
Do you find other pleasures (non food and drink) as enjoyable? Interesting to hear if it’s selective or dampens everything.
[+] [-] paulpauper|2 years ago|reply
[+] [-] c7DJTLrn|2 years ago|reply
[+] [-] raincom|2 years ago|reply
[+] [-] remote_phone|2 years ago|reply
[+] [-] usernew|2 years ago|reply
I used to lift and be real fit till about 40. Like bulky-lean looking, bench 400 10x with a 6pack. Had a lot to do with being on the road for work all over the world, and you sit at the gym at the hotel for an hour every night because of nothing else to do, and there are girls there also on business who you'll never see again. I drank A Lot, ate anything I wanted, and did lots of blo on weekends.
It was getting out of control, so I did months of google-foo, went to a pharmacy in eastern europe, got like a thousand 150mg disulfiram pills under the counter for fifty bucks, and took one pill every morning for 2 years. You don't drink, you can't drink or you die, you forget drinking exists and after a couple of months don't even think about it, yet still do all the same stuff you used to - like dancing and clubs if that's your thing. And it's even more fun. There were no side effects.
Then things changed with age, testosterone went to crap, joints hurt. I got married and settled down. Can't work out too much now - just a couple of hours per week, and no heavy weights. Within 2 years I couldn't fit into my clothes and had high blood pressure and high cholesterol.
I realized I don't eat because I'm hungry, but because it keeps away sadness. So I changed my diet so I could eat however much I want. I now have a 4-pack instead of 6, fit into my pants, and eat however much I want.
I cut out fat completely. No oil when I cook besides a light spray on the frying pan. No nuts. Tuna - not salmon. Real expensive lean filet if I want cow in my mouth. Only white meat from birds. All the pasta, rice, and potatoes I want, but zero sugar added to anything. Lots of splenda and sweet n low. Fat free fairlife milk (lactose filtered out = less sugar calories). I eat normal sized meals.
Then, I have fruit and berries, and I eat as much of that as I want. I'm stuffing my face the whole day. Today, I had a pint of blueberries, 5 medium apples, 2 mangoes, and a pound of grapes.
Speaking of gastrointestinal issues, my poo is now soft and gentle, and smells delicious.
[+] [-] yieldcrv|2 years ago|reply
like thats not something I’m deriding its just news to me
makes me wonder what this drug actually does, flush gut bacteria? just the right ones?
[+] [-] lumb63|2 years ago|reply
The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energy and has developed issues with her bladder, circulatory system, joints, thyroid, and digestive system since starting Ozempic. I’m not saying it’s due to Ozempic, but I am saying all these issues have cropped up in the few months since she started taking it, and she never had any chronic health issues prior. At least she lost some weight, I guess.
[+] [-] reaperman|2 years ago|reply
- blood pressure
- lipids (HDL, LDL)
- insulin sensitivity
- blood glucose
- strokes
- cardiovascular events + deaths
- myocardial infarctions
- hemoglobin A1C,
- revascularization,
- etc, etc, etc
are literally all affected positively (to the benefit of the imaginary "mean" patient) in bulk.
Note though, that doesn't mean 100% of patients are have positive results, just that each of these are, in bulk, positive across the tested subjects when averaged together. There's little in the data to suggest that cases like your family member aren't happening or couldn't happen.
There's also evidence that GLP-1 agonists increase the rate of glucose use in the brain, accelerating learning rates. (The brain accounts for 2% of body weight but up to 25% of glucose consumption, it really is fueled by glucose)
https://clinicaltrials.gov/ct2/show/NCT00256256?term=stroke&...
[+] [-] MandieD|2 years ago|reply
Because it’s so wonderfully effective for the majority, there ends up being a ton of social and economic pressure for anyone even slightly overweight to take it, despite said 10% risk of death.
(Edited to add):
“The Pill,” by Meg Elison
https://escapepod.org/2022/11/03/escape-pod-861-the-pill-par...
https://escapepod.org/2022/11/10/escape-pod-862-the-pill-par...
[+] [-] SystemOut|2 years ago|reply
About 6 months ago there was a posting about Ozempic and I had said something to the effect that it wasn't worth it watching some of the side effects my wife had from it. And then I went to the doctor for a check-up and lo and behold I had diabetes. Asymptomatic, but an A1C of 11. My doctor re-ran the test because he didn't believe it and it doesn't run in my family. My cholesterol had also jumped and he said he was going to put me on a statin after the initial 3 months of adjusting to the diabetes medication.
My Dr. puts me on Ozempic and I grumble about it but with that test results I had, I knew I had to do something. Fast forward 3 months, I dropped 20 pounds, and every other measurement is back in the green, including my A1C. Now, I made some serious lifestyle changes and ate a diabetic diet (limiting carbs, the types of carbs, etc), and have been keeping up with being more active but my entire relationship with food has changed because of Ozempic. Before I had a near compulsion to eat more than I should. Now, I don't because one, I feel fuller quicker and two, I know I'll feel horrible for hours if I over-eat. It only took one of those events to never want to do that again. I can't really explain why but I also don't have as strong of a desire to eat foods that are bad for me. I really thought I'd battle the cravings more after going cold turkey from "bad" foods. I can't say why it is but it's true. Side note, going to the grocery story was really difficult at first....there is so much sugar in the American food supply.
Energy wise I will say that I did struggle with low energy initially as my body adapted to lower calorie intake but I also learned that when I found the right balance of protein/complex carbs for me that my energy levels came back up and I now feel better than ever.
My doctor was shocked. I've never seen him that animated when I came back in for the 3 month follow-up. I didn't need to add any additional medications and they're slowly adjusting me back towards a single medication.
[+] [-] cameronh90|2 years ago|reply
If anything, my energy levels actually went up immediately after starting it. Normally I was pretty sluggish but it felt like some extra firepower was unlocked.
Everything has risks and benefits, and might harm some people. I hope your family member gets better soon.
[+] [-] burnte|2 years ago|reply
I still have pretty big appetite suppression, and only minimal nausea sometimes if I eat too much, but what it's done to my blood glucose is AMAZING. And I lost some weight when I started which was a great bonus. It can be hard to start but it's truly worth it, just adjust the dose. I take 0.5mg as I can't handle the larger 1.0mg dose.
[+] [-] vrc|2 years ago|reply
[0] https://www.hopkinsmedicine.org/news/media/releases/johns_ho...
[1] https://www.aafp.org/pubs/afp/issues/2007/0515/p1513.html
[+] [-] ortusdux|2 years ago|reply
Reminds me of the first FDA approved weight loss drug, Alli, that basically just gastrointestinally punishes you if you eat more than a few grams of fat.
https://en.wikipedia.org/wiki/Orlistat#Side_effects
[+] [-] crazygringo|2 years ago|reply
I'm sure I'd easily lose weight with Ozempic but I'd still be suffering health issues. Not because of Ozempic itself but just because I wouldn't be getting enough calories, despite still being above a healthy weight.
[+] [-] ESTheComposer|2 years ago|reply
[+] [-] kristofferR|2 years ago|reply
For those people who tolerate the drug well, it can be revolutionary in their lives, but it's unfortunately not a good fit for everyone.
I hope your family member gets better soon.
[+] [-] etchasketch|2 years ago|reply
[+] [-] ex3ndr|2 years ago|reply
[+] [-] smith7018|2 years ago|reply
[+] [-] ikekkdcjkfke|2 years ago|reply
[+] [-] renewiltord|2 years ago|reply
[deleted]
[+] [-] jshaqaw|2 years ago|reply
I think the “fit” of the world get inherently uncomfortable that our relative social currency is being “devalued” if everyone can be like us with an “unearned” pill. And it comes out as hostility and skepticism.
I admit haven’t done much research on this particular topic. History should caution us that serious medication like this often has serious side effects which are not apparent early on. I get that. But unlike many others I don’t “hope” that happens like some kind of moral balancing. I get that reaction. In my gut I have that “I did it with willpower and lifestyle and sweat and these people shouldn’t just get it at CVS.” But that’s just the primate status brain talking.
Not that it impacts the outcome but I sincerely hope these drugs can improve people’s lives without significant negative problems. I can find my relative status elsewhere or better yet try to grow up past such impulses.
[+] [-] joedevon|2 years ago|reply
[+] [-] briHass|2 years ago|reply
It's also downright laughable how the media/Youtube influencers/etc. treat everyone like idiots. Men's Health will run an article on Mr. Moviestar who was 5'11' and 150 pounds before his role as Superhero Character got to 200 pounds and veiny biceps in 6 months by eating eggs, oatmeal, and chicken breast and doing some situps.
[+] [-] LazyMans|2 years ago|reply
[+] [-] AtlasBarfed|2 years ago|reply
The drug probably helped.
[+] [-] burnished|2 years ago|reply
[+] [-] rjbwork|2 years ago|reply
[+] [-] unknown|2 years ago|reply
[deleted]
[+] [-] mym1990|2 years ago|reply
From what I have heard, all of these issues come back as soon as someone comes off the drug. So either a person is committing to a lifetime of being dependent on this drug, or a person is committing to some period of time of ideal living, followed by a possible time of depression after reverting to the status quo.
[+] [-] glonq|2 years ago|reply
After having learned potentionally nothing about nutrition, exercise, and self-control, are you stuck on these meds for life out of fear of binge-eating back to your original weight?
FWIW I'm on a hundred-pound roller coaster ride from 300lbs to 200lbs; currently ~215. I've learned a lot about discipline and sustainable habits along the way.
[+] [-] rektide|2 years ago|reply
The wonderful Paul Ford has the best writeup I've seen that discusses these more meta levels, the post-human implications of a drug we can genuinely widescalely reprogram ourselves with. Paul's so great. https://www.wired.com/story/new-drug-switched-off-appetite-m... https://news.ycombinator.com/item?id=34660232
[+] [-] SamoyedFurFluff|2 years ago|reply
[+] [-] xvilka|2 years ago|reply
[+] [-] monkeycantype|2 years ago|reply
there are some great papers on fat labradors that hint at how these different genotypes are linked to our desire to eat and how that shifts our behaiour. Guide dogs are highly selected for trainability, and positive reinforcement with food reward plays an important role in their training. I think it was Yeo, found 22% of pet Labradors and 80% of Labrador guide dogs sampled carried a 14 BP deletion in the POMC gene, which forms part of this pathway.
https://doi.org/10.1007/s00125-016-4187-x https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873617/
[+] [-] arcadeparade|2 years ago|reply
[+] [-] MagicMoonlight|2 years ago|reply
Normies have it so easy. They take one bite and feel full. My brain would scream at me continuously to try and make me eat and would never be satisfied.
[+] [-] fintechie|2 years ago|reply
The results are exactly the same... you fill full eating less quantity, cravings disappear after 1-2 weeks, increased focus and enhanced mental state. But yeah, you need some self-discipline, tons of coffee/matcha and water.
I've concluded that semaglutide is not for me. Just like self-discipline in pills, with potential side effects. So better to give IF another go... I'm in the 4th week and dropped 10lbs already.
[+] [-] TeeMassive|2 years ago|reply
It also has a repressive effect on drinking and smoke, to my great surprise. And it also has had an effect on my addiction to video games.
Drugs companies get a lot of slack (most of the time deserving) but sometimes they create miracles pills.
[+] [-] crakenzak|2 years ago|reply
[+] [-] beefman|2 years ago|reply
[+] [-] caycep|2 years ago|reply
to whit, (like botox), all the initial promises of the stuff have been waaaay overshadowed by...cosmetic value.
(I'm oversimplifying a bit...for those who are morbidly obese, yes, the weight loss really helps, but then they also have diabetes most likely which is the primary indication of the drug)
[+] [-] PostOnce|2 years ago|reply
Ozempic costs money and its side effects include cancer, kidney failure, and ruining your eyes.
https://www.ozempic.com/faqs.html
edit: many point out calorie intake is the real problem, it's true: buy a kitchen scale, weigh your food, count your calories, and you will lose weight. Exercise is optional compared to that. Still, both are free and have more benefits.
[+] [-] omgmajk|2 years ago|reply
[+] [-] EdwardDiego|2 years ago|reply
People who are addicted will repeat the behaviour even without the neurochemical response. Consider the ritual of the addiction as a form of self-soothing.
You have to treat the patterns we've trod in our own minds, as well as removing that biological reinforcement.