The anti vax screw will probably wonder if injecting the vaccine actually increases your odds of Alzheimers since you're getting a partial version of the virus when doing so.
Not really. They used the cutoff date to develop a theory. That is, those before the date couldn't get the vax vs those after the date that did.
So far, so good.
However, not everyone after the date got the vax. That is, like tge before date "control" there are a post-date group who also did not get the vax. Oddly, there's no mention how this group fared.
Obviously, they know this group exist. And that the initial theory would be ideal to apply to this group. That didn't happen.
That would be definite. As it is, a key and obvious piece is missing.
“ With childhood varicella vaccination in the United States have come concerns that the incidence of herpes zoster may increase, because of diminishing natural exposure to varicella and consequent reactivation of latent varicella zoster virus.”
“As the rates of VRHDs and the associated charges have decreased, there has been a significant increase in HZHDs and associated charges, disproportionately among older adults.”
The chickenpox vaccine absolutely decreases the chances of the people getting the vaccine of getting dementia. This has a side-effect of decreasing the exposure of older adults to new chickenpox infections, which increases their odds of developing shingles.[1]
But as long as those older adults are getting the shingle vaccine, their odds of getting dementia should reduce as well.
[1] - Intermittent infection with chickenpox boosts the adaptive immune response to the chronic chickenpox infection that most people who ever caught the disease have. This intermittent boosting helps prevent flareups of the chronic chickenpox infection (also known as shingles), which is likely the causative factor in chickenpox-related dementia. Alternatively, instead of getting intermittently infected with chickenpox, they could just get a shingles vaccine instead to boost their immune response against their previously acquired chronic infection.
I presume that this intermittent exposure to chickenpox is greatest in adults with children (and grandchildren). Possibly explaining the decrease in dementia for older people with adult children: https://www.sciencedirect.com/science/article/pii/S235282732...
> Having 3+ children, adult daughter(s), or biological children was associated with lower risk of cognitive impairment.
The vaccine may indirectly increase the risk that people who did not receive the vaccine get shingles. As far as we know, people who got the chickenpox generally don’t get shingles.
slashdev|2 years ago
chiefalchemist|2 years ago
So far, so good.
However, not everyone after the date got the vax. That is, like tge before date "control" there are a post-date group who also did not get the vax. Oddly, there's no mention how this group fared.
Obviously, they know this group exist. And that the initial theory would be ideal to apply to this group. That didn't happen.
That would be definite. As it is, a key and obvious piece is missing.
pohl|2 years ago
tempfortwitt90|2 years ago
[deleted]
DaniloDias|2 years ago
tempfortwitt90|2 years ago
Nextgrid|2 years ago
khazhoux|2 years ago
e44858|2 years ago
“ With childhood varicella vaccination in the United States have come concerns that the incidence of herpes zoster may increase, because of diminishing natural exposure to varicella and consequent reactivation of latent varicella zoster virus.”
“As the rates of VRHDs and the associated charges have decreased, there has been a significant increase in HZHDs and associated charges, disproportionately among older adults.”
anonymouskimmer|2 years ago
But as long as those older adults are getting the shingle vaccine, their odds of getting dementia should reduce as well.
[1] - Intermittent infection with chickenpox boosts the adaptive immune response to the chronic chickenpox infection that most people who ever caught the disease have. This intermittent boosting helps prevent flareups of the chronic chickenpox infection (also known as shingles), which is likely the causative factor in chickenpox-related dementia. Alternatively, instead of getting intermittently infected with chickenpox, they could just get a shingles vaccine instead to boost their immune response against their previously acquired chronic infection.
I presume that this intermittent exposure to chickenpox is greatest in adults with children (and grandchildren). Possibly explaining the decrease in dementia for older people with adult children: https://www.sciencedirect.com/science/article/pii/S235282732...
> Having 3+ children, adult daughter(s), or biological children was associated with lower risk of cognitive impairment.
amluto|2 years ago