[ArchieMaclean]

I use Colemak-DH (modified version of Colemak that has less lateral hand motion - found I was getting slight wrist strain with normal Colemak). I find it more comfortable than Qwerty. I have not had any issue with keyboard shortcuts - Ctrl-Z/X/C are in exactly the same spot and Ctrl-V is shifted over by one key. Most shortcuts are placed to be memorable (e.g. Ctrl-F for Find), not to be ergonomic, so the keyboard layout doesn't really matter. The only place I've really had to customise is Vim, where I've remapped the motion keys back to where they are in Qwerty (actually shifted over by one to j/k/l/;).

On Gnome, switching keyboard layout is very quick and easy - there's an icon in the top bar by default - so I can use that when other people want to use my computer. When I use others' computers, I have to look at the keyboard but it is not too much hassle for me as I don't do this very often.

The main issue I've actually had is remapping Caps Lock to Back Space - not trivial to do in Gnome (required creating my own layout in XDG).

[dillydogg]

You can rebind caps to backspace in GNOME. I think you use GNOME tweaks. I've done it on all of my computers.

[ArchieMaclean]

I did this initially, but I believe it didn't work for all applications - some were still registering it as Caps Lock (e.g. VS Code IIRC).