[dloreto]

The stated downsides come from poor data locality when using mostly random UUIDs; but you can keep most of the benefits of a globally unique identifier, and retain locality, by using UUIDv7.

At jetpack.io we've been doing exactly that via TypeIDs: https://github.com/jetpack-io/typeid and there's a PostgresSQL implementation available. TypeIDs are UUIDv7 with additional type information, so you also get type-safety in your IDs.