[Lapha]

While it's not a direct parallel, I'd recommend people be careful with using your thumbs like this. I've been using a tiling window manager with the windows key as a modifier for years, but recently I've been having problems with strain in my thumb from switching workspaces 1-4 and toggling fullscreen/tiling (t and f keys). Had I used alt instead of the windows key it might have alleviated some of the problems as it's shifted to the right, but my hand position still ends up in the same position that gave me problems if I try to alt 4-6, e-t or d-g.

One remap I can fully recommend is remapping caps lock to control, it's an incredibly natural position to hit the very common ctrl-w,r,t,f,c,v hotkeys.