[clemesha]

This is how I feel about Flask. I've been using it with Backbone.js and they make a great combo: Flask API serving JSON, and the rest of the logic on the client.

[eddie_the_head]

You might find these demoes of Flask with pjax interesting then:

http://flaskpjax.herokuapp.com/automobiles

https://bitbucket.org/a2c/pjax_flask/overview

[ch0wn]

If you go down the API route, Flask-Restless[0] and simpleapi[1] are also worth a look.

[0] http://readthedocs.org/docs/flask-restless/en/latest/ [1] https://github.com/flosch/simpleapi

[SkyMarshal]

I believe Twitter and Foursquare are doing this too. Their Scala-based appservers are API endpoints, serving JSON to the javascript/Backbone.js frontend.