I picked up the Miryoku layout a year or two ago and the home row mods (Ctrl, alt, shift...) make all the difference. Adding a thumb key into the shortcut to hit a key on a layer doesn't take much extra mental energy and it becomes muscle memory for certain shortcuts. It's a little like playing different chords on the piano. I added some customization for Vim arrow keys and now I don't think I'll ever go back.
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