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dablweb | 2 years ago
Natural mRNA is too unstable to reliably transport into the cell via injection. Part of the reason mRNA gene treatments spent so long in development without a single approved product.
The two technologies that facilitate this techonology are:
1. Base-modified mRNA (modRNA or :( mRNA), where they substitue uridine.
2. Nano-technology which protects the payload in a bubble of fat, lipid-nano-particles (LNPs).
While LNPs on their own are capable of their own side effects, the modRNA is particularly worrying because of its extended lifetime. IIRC some studies claim to have found it intact many weeks after injection, which would be astounding were we talking of natural mRNA.
Bret Weinstein said of this situation "if a fiberglass tree falls in the forest", which illustrates that most biologists and medical professionals could estimate how long a tree would take to decompose in a forest, however, their estimates would be wildly incorrect if you omitted to tell them the tree was made of fiberglass.
The podcast where he discusses this is here: https://open.spotify.com/episode/5Qyhu8A4wuCPkvCXM0KLut
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