[Nevaeh]

Creating resistance to avian influenza infection through genome editing of the ANP32 gene family: https://www.nature.com/articles/s41467-023-41476-3

"These mutations unexpectedly allowed the usually host-restricted avian influenza polymerase to use the shorter human ANP32A and B and thus partially adapted the viral polymerase for replication in mammals. Although unintended, this consequence clearly indicates the importance of a robust genome editing strategy and subsequent appraisal that includes challenge with multiple avian influenza genotypes at non-physiological exposure levels to rule out the opportunity for adaptive viral evolution."