[raydiatian]

> at levels that only result in a little dizziness.

Anecdotal first hand account, I would have to completely disagree with you. I tried intravenous ketamine therapy about a year ago. I’m plenty experienced with psychoactives, having experienced several at varying doses, so I knew what I was in for. My IVKT experience was a full on trip, definitely not just passive dizziness.

[astrange]

Is it possible that being an experienced tripper (psychonaut?) sensitizes you to new psychoactives?

[TheFattestNinja]

While I can imagine it's possible that usage of substance A "breaks" new ground in your sensitivity to substance B by "opening" some new pathways, I find it unlikely:

The "standard" pathways for most substances is to build a tolerance to it (and similar compounds) over time of use. If you drink coffee a lot you don't get hyped by the same dose of caffeine, if you drink lots of alcohol it's harder to get you drunk, etc.

So if anything I'd expect "veterans" to be less sensitive to it. But there are substances that permanently reduce your tolerance to them, usually by causing some form of permanent damage, so it's possible that you might "break" something limiting your experience.