[k0k0]

> Ibuprofen is probably the safest option?

Are you kidding? Ibuprofen like most NSAIDS is terrible on the GI tract and the kidneys. People with healthy kidneys are usually fine with short courses, but even people with relatively mild chronic kidney disease should avoid NSAIDs.

People in their 20s that overuse NSAIDs end up needing kidney transplants. it's not that uncommon. The most common cause of peptic ulcer disease of this demographic (affluent westerners) after H pylori is NSAID use.

> It has fallen out of favor because it's known to cause an exceedingly rare but deadly syndrome in a tiny percentage of children

This has really nothing to do why aspirin has less common use among adults. Aspirin has poor analgesic effects relative to the doses and the risks of GI complications.

> acetaminophen results in tons of hospitalizations every year.

The impact of NSAID related complications is far greater in terms of kidney transplants and upper endoscopy interventions, and related ICU stays.