[jfarlow]

There are a number of companies working on 'in vivo' deliveries for CARs. Oftentimes using the same tools as proven out by the Moderna vaccine.

[puzzlingcaptcha]

Yes, but that way you lose control over the dose, and to an extent over CAR-T characteristics. CAR-T therapy is usually used in patients who already had multiple rounds of chemo and their immune cells are generally not in a great shape. Even with 'traditional' CARs you occasionally get manufacturing failures since the cells are too exhausted to expand in vitro or have already lost their effector functions.