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benchtobedside | 2 years ago

Worth noting that 23andMe, plus many other low cost genealogy/health-focused companies do not sequence your DNA.

Instead, they perform what is called a genotyping microarray test, which looks at less than 0.1% of your genome.

To quote from 23andMe: "In order to be genotyped, the amplified DNA is “cut” into smaller pieces, which are then applied to our DNA chip (also known as a microarray), a small glass slide with millions of microscopic “beads” on its surface. Each bead is attached to a “probe," a bit of DNA that matches one of the genetic variants that we test. The cut pieces of your DNA stick to the matching DNA probes. A fluorescent label on each probe identifies which version of that genetic variant your DNA corresponds to."

Source: https://customercare.23andme.com/hc/en-us/articles/227968028...

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